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Human papillomavirus is independent prognostic factor on outcome of oropharyngeal squamous cell carcinoma

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Tumor Biology

Abstract

The primary aim of this study is to assess differences in patients’ clinicopathological characteristics based on human papillomavirus (HPV) status and the effect of HPV status on outcome in oropharyngeal squamous cell carcinoma (OSCC). The medical registry of 81 patients who were treated for OSCC was retrospectively analyzed. Factors that are found to be predictive of poor overall survival and event risk by univariate Cox’s regression analysis included age greater than 60 years (hazard ratio (HR), 1.2, p = 0.02, and HR, 1.12, p = 0.05), poor Eastern Cooperative Oncology Group performance (HR,1.6, p = 0.01, and HR,1.32, p = 0.001), advanced T stage (HR,1.38, p = 0.01, and HR,1.4, p = 0.02), advanced N stage(HR, 1.6, p = 0.03, and HR,1.5, p = 0.03), smoking history (HR,1.4, p = 0.04, and HR, 1.6, p = 0.03), and HPV-negative patients (HR, 2.4, p = 0.012, and HR, 1.8, p = 0.01). HPV-positive tumors were estimated to have a 36 % reduction in risk of death and 32 % reduction in event risk. HPV status had independent prognostic effects on survival and event-free survival.

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Authors and Affiliations

  1. Division of Medical Oncology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, 34098, Istanbul, Turkey

    Deniz Tural & Süheyla Serdengeçti

  2. Department of Radiation Oncology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey

    Olgun Eliçin & Ömer Uzel

  3. Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey

    Şebnem Batur & Büge Öz

  4. Division of Medical Oncology, Department of Internal Medicine, Medical Faculty, Akdeniz University, Antalya, Turkey

    Deniz Arslan

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  1. Deniz Tural
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  2. Olgun Eliçin
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  3. Şebnem Batur
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  4. Deniz Arslan
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  5. Büge Öz
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  6. Süheyla Serdengeçti
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  7. Ömer Uzel
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Correspondence to Deniz Tural.

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Tural, D., Eliçin, O., Batur, Ş. et al. Human papillomavirus is independent prognostic factor on outcome of oropharyngeal squamous cell carcinoma. Tumor Biol. 34, 3363–3369 (2013). https://doi.org/10.1007/s13277-013-0907-8

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  • DOI: https://doi.org/10.1007/s13277-013-0907-8

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