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Association of a novel antisense lncRNA TP73-AS1 polymorphisms and expression with colorectal cancer susceptibility and prognosis

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Abstract

Background

TP73-AS1 is a novel antisense long noncoding RNA and plays an important role in cell proliferation and cancer development. However, the link between TP73-AS1 and colorectal cancer (CRC) has not yet been reported.

Objective

To explore the association of genetic variants in TP73-AS1 and its expression with CRC susceptibility and prognosis.

Methods

A case–control study (including 507 CRC cases and 503 controls) and bioinformatics analysis were conducted.

Results

rs9800 polymorphism was significantly related to higher risk in CRC [adjusted odds ratio (AOR) = 1.33, 95% confidence interval (CI) = 1.02–1.75, P = 0.034 in heterozygote codominant model]. There was no difference between TP73-AS1 polymorphisms and different tumor node metastasis (TNM) stages in the adjusted model. Moreover, TP73-AS1 expression level was positively related to different TNM stages. After adjusted for age, gender and TNM, higher TP73-AS1 expression levels were related to shorter recurrence-free survival time [hazard ratio (HR) = 1.66, 95% CI = 1.02–2.71, P = 0.043].

Conclusion

TP73-AS1 polymorphisms and expression may be associated with susceptibility and prognosis of CRC.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (Grant No. 81302506), Research on the Application of Public Welfare Technology of Zhejiang Province (No. 2014C33224), Natural Science Foundation of Zhejiang Province (No. LQ18H260002), and Medical Science and Technology Project of Zhejiang Province (No. 2018KY353).

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Authors and Affiliations

  1. Department of Public Health, Hangzhou Medical College, 481 Binwen Road, Binjiang District, Hangzhou, 310053, Zhejiang, China

    Jiayao Fan, Huiqing Xu, Fangyuan Jing & Chunhong Fan

  2. Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, China

    Bing Liu

  3. Department of Chronic Non-Communicable Diseases Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China

    Qingfang He

  4. Department of Nutrition, California Baptist University, Riverside, CA, USA

    Shasha Zheng

  5. Mucosal Immunology and Biology Center, Massachusetts General Hospital, Charlestown, MA, USA

    Haining Shi & Lefei Jiao

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  1. Jiayao Fan
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  2. Huiqing Xu
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  4. Fangyuan Jing
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  9. Chunhong Fan
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Correspondence to Chunhong Fan.

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Ethical approval

This study was approved by the Medical Ethical Committee of Hangzhou Medical College. The informed consent was signed by all participants at the time of recruitment.

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Fan, J., Xu, H., Liu, B. et al. Association of a novel antisense lncRNA TP73-AS1 polymorphisms and expression with colorectal cancer susceptibility and prognosis. Genes Genom 44, 889–897 (2022). https://doi.org/10.1007/s13258-021-01161-5

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  • DOI: https://doi.org/10.1007/s13258-021-01161-5

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