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Electromagnetic induction sensor for dynamic testing of coagulation process

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Abstract

With the increasing demand for coagulation POCT for patients in the surgery department or the ICU, rapid coagulation testing techniques and methods have drawn widespread attention from scholars and businessmen. This paper proposes the use of electromagnetic induction sensor probe for detection of dynamic process causing changes in the blood viscosity and density before and after coagulation based on the damped vibration principle, in order to evaluate the coagulation status. Utilizing the dynamic principle, the differential equation of vibration system comprising elastic support and electromagnetic induction device is established through sensor dynamic modeling. The structural parameters of elastic support are optimized, and the circular sheet spring is designed. Furthermore, harmonic response analysis and vibration fatigue coupling analysis are performed on the elastic support of the sensor by considering the natural frequency of the system, and the electromagnetic induction sensor testing device is set up. Using the device and coagulation reagent, the standard curve for coagulation POCT is plotted, and the blood sample application in clinical patients is established, which are methodologically compared with the imported POCT coagulation analyzer. The results show that the sensor designed in this paper has a first-order natural frequency of 11.368 Hz, which can withstand 5.295 × 102 million times of compressions and rebounds. Its correlation with the results of SONOCLOT analyzer reaches 0.996, and the reproducibility 0.002. The electromagnetic induction coagulation testing sensor designed has good elasticity and anti-fatigue, which can meet the accuracy requirement of clinical detection. This study provides the core technology for developing the electromagnetic induction POCT instrument for dynamic testing of coagulation process.

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Funding

This study was funded by the Natural Science Foundation of Jilin Province (Grant Number 20140309013YY).

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Authors and Affiliations

  1. Changchun University of Science and Technology, Changchun, 130022, China

    Zhe Wang, Yuanhua Yu, Zhanjiang Yu & Qimeng Chen

  2. School of Science, Changchun University of Science and Technology, Changchun, 130022, China

    Zhe Wang

  3. Key Laboratory of Biological Detection Engineering, Changchun, 130022, China

    Yuanhua Yu

  4. Precision Manufacturing and Testing Technology National Local Joint Engineering Laboratory, Changchun, 130022, China

    Zhanjiang Yu

  5. Key Laboratory of Optical Control and Optical Information Transmission Technology, Department of Education, Changchun, 130022, Jilin, China

    Qimeng Chen

Authors
  1. Zhe Wang
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  2. Yuanhua Yu
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  3. Zhanjiang Yu
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  4. Qimeng Chen
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Correspondence to Zhe Wang.

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All authors declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Informed consent was obtained from all individual participants included in the study.

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Wang, Z., Yu, Y., Yu, Z. et al. Electromagnetic induction sensor for dynamic testing of coagulation process. Australas Phys Eng Sci Med 41, 105–115 (2018). https://doi.org/10.1007/s13246-018-0618-y

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  • DOI: https://doi.org/10.1007/s13246-018-0618-y

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