Skip to main content
SpringerLink
Log in

Anti-Cancer Evaluation of Mineral Colloids Against MCF-7 Cell Lines: An Investigation Through Thermal Spring Water

  • Article
  • Published:
Macromolecular Research Aims and scope Submit manuscript

Abstract

Presently, thermal spring water, as a rich source of mineral colloids (MCs) and other elements, has been used for treating various diseases. However, its therapeutic effects on different types of cancer including breast cancer (BC) have not been reported so far. In this study, we analyzed the characterization of nanoparticles presented in MCs of thermal spring water in Rabor County, Kerman Province, Iran. We conducted the present study using X-ray fluorescence spectra, inductively coupled plasma mass spectrometry, X-ray powder diffraction, and transmission electron microscopy methods. We compared the oxidative evaluation of MCs with the control group using the 2,2-diphenyl-1-picrylhydrazyl test. Also, the anti-cancer influences of MCs against BC cell lines (MCF-7) were assessed and compared with the human fibroblast cells (hFCs) using the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) test. Finally, we investigated the impact of MCs on the liver and kidney tissues of normal rats. Results of this study confirmed the presence of various oxides, including SiO2, Al2O3, and CaO, as well as elements, such as Sr, V, and Cr, in MCs. Moreover, our results showed that with an increase in the concentration of used MCs, the cell survival of cancer cell lines significantly decreased compared to hFCs. Also, no histologic change was observed in normal tissues exposed to MCs; however, MCs that existed in thermal spring water showed a considerable anti-cancer effect against BC cell lines.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S. Attalla, T. Taifour, T. Bui, and W. Muller, Oncogene, 40, 475 (2021).

    Article  CAS  PubMed  Google Scholar 

  2. P. M. Gaye, M. B. Ba, F. N. Sarr, F. Niang, M. Mané, and F. C. A. Chemega, Adv. Breast. Cancer. Res., 10, 133 (2021).

    Article  Google Scholar 

  3. X. Han, X. Duan, Z. Liu, Y. Long, C. Liu, J. Zhou, N. Li, J. Qin, and Y. Wang, Breast. Cancer. Res. Treat, 188, 329 (2021).

    Article  CAS  PubMed  Google Scholar 

  4. Y. Jin, Y. J. Choi, K. Heo, and S. J. Park, Int. J. Mol. Sci., 22, 438 (2021).

    Article  CAS  PubMed Central  Google Scholar 

  5. R. Moradpoor and M. Salimi, Iran. Biomed. J., 25, 1 (2021).

    Article  PubMed  Google Scholar 

  6. B. Sasanfar, F. Toorang, F. Maleki, A. Esmaillzadeh, and K. Zendehdel, Public Health Nutr., 24, 965 (2021).

    Article  PubMed  Google Scholar 

  7. Y. Wang, X. Zhou, W. Wang, Y. Wu, Z. Qian, and Q. Peng, Chin. Chem. Lett., 32, 3687 (2021).

    Article  CAS  Google Scholar 

  8. Y. Hussain, L. Islam, H. Khan, R. Filosa, M. Aschner, and S. Javed, Phytother. Res., 35, 6514 (2021).

    Article  CAS  PubMed  Google Scholar 

  9. S. Luan, X. Zeng, C. Zhang, J. Qiu, Y. Yang, C. Mao, X. Xiao, J. Zhou, Y. Zhang, and Y. Yua, Front Cell. Dev. Biol., 9, 664816 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  10. P. Pascoal-Ferreira, D. Glez-Peña, C. Miranda, P. Poeta, J. Coutinho, F. Fdez-Riverola, A. Torrado-Agrasar, M. Luisa Rúa, and G. Igrejas, Water., 13, 1439 (2021).

    Article  CAS  Google Scholar 

  11. D. Passali, G. Gabelli, G. C. Passali, R. Mösges, and L. M. Bellussi, Otolaryngol Pol., 71, 8 (2017).

    Article  PubMed  Google Scholar 

  12. J. Liang, D. Kang, Y. Wang, Y. Yu, J. Fan, and E. Takashi, PLoS One., 10, 0117106 (2015).

    Google Scholar 

  13. K. Kubota, I. Machida, K. Tamura, H. Take, H. Kurabayashi, T. Akiba, and J. Tamura, Acta. Derm. Venereol., 77, 452 (1997).

    CAS  PubMed  Google Scholar 

  14. F. J. Teixeira and C. S. Gomes, Mineral Water: Essential to Life, Health, and Wellness, in Minerals latu sensu and Human Health., Springer 517–556 (2021).

  15. H. S Fiffy, G. Elia, H. N. Hizami, H. Zulhazman, M. N. Nordiana, and A. A. Nor Akmar, IOP Conf Ser Earth Environ Sci., IOP Publishing (2021).

  16. F. A. Birami, F. Moore, M. R. Kardan, B. Keshavarzi, M. Zarei, and P. S. Hooda, Environ Earth Sci., 80, 1 (2021).

    Article  Google Scholar 

  17. X. Tan, B. Bo, P. Zhang, G. Shao, R. Liu, and K. Wang, Environ. Chem. Lett., 1–6 (2021).

  18. E. Tomaszewska, K. Ranoszek-Soliwoda, K. Sztandera, P. Błażałek, R. Głowacki, A. Janaszewska, B. Janasik, G. Celichowski, W. Wasowicz, B. Klajnert-Maculewicz, and J. Grobelny, Chemistry Select., 6, 1230 (2021).

    CAS  Google Scholar 

  19. C. Dong, A. Ma, and L. Shang, J. Nanopart. Res., 23, 172 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  20. S. S. Al-Jameel, S. Rehman, M. A. Almessiere, F. A. Khan, Y. Slimani, N. S. Al-Saleh, A. Manikandan, E. A. AlSuhaimi, and A. Baykal, Artif Cells Nanomed Biotechnol., 49, 493 (2021).

    Article  CAS  PubMed  Google Scholar 

  21. H. Wang, Y. Zhou, Q. Sun, C. Zhou, S. Hu, C. Lenahan, W. Xu, Y. Deng, G. Li, and S. Tao, Front Bioeng Biotechnol., 9, 106 (2021).

    Google Scholar 

  22. K. I. Alsamhary, Saudi. J. Biol. Sci., 27, 2185 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Z.-L. Chi and G.-H. Yu, Sci. China. Earth Sci., 1–11 (2021).

  24. M. Pietrzak and P. Ivanova, Bimetallic and Multimetallic Nanoparticles as Nanozymes. Sens. Actuators B Chem., 336, 129736 (2021).

    CAS  Google Scholar 

  25. M. Hajibeygi and S. Faramarzinia, Polym Compos., 42, 5904 (2021).

    Article  CAS  Google Scholar 

  26. H.-J. Kim, F. Chen, C. Wu, X. Wang, H. Y. Chung, and Z. Jin, J. Agric. Food. Chem., 52, 2849 (2004).

    Article  CAS  PubMed  Google Scholar 

  27. E.-T. Heakal, F. O. S. Shehata, and N. S. Tantawy, Corros. Sci., 86, 285 (2014).

    Article  CAS  Google Scholar 

  28. H. A. Kadhem, S. A. Ibraheem, M. S. Jabir, A. A. Kadhim, Z. J. Taqi, and M. D. Florin, Nano. Biomed. Eng., 11, 35 (2019).

    Article  CAS  Google Scholar 

  29. Z. Naeimi, A. Neamati, and M. Homayouni-Tabrizi, Kaums Journal (FEYZ)., 23, 241 (2019).

    Google Scholar 

  30. W. A. J. P. Wijesinghe, Y. JinJeon, P. Ramasamy, M. E. A. Wahid, and C. S. Vairappan, Food Chem., 139, 326 (2013).

    Article  CAS  PubMed  Google Scholar 

  31. P. Zhou, H. Zhao, Q. Wang, Z. Zhou, J. Wang, G. Deng, X. Wang, Q. Liu, H. Yang, and S. Yang, Adv. Healthc Mater., 7, 1701201 (2018).

    Article  CAS  Google Scholar 

  32. R. Sattari, G. R. Khayati, and R. Hoshyar, Mater. Chem. Phys., 241, 122438 (2020).

    Article  CAS  Google Scholar 

  33. A. Rohiman and A. S. Arifin, Indones. Rev. Phys., 31, 24 (2020).

    Article  Google Scholar 

  34. A. A Athirah, Int. J. Integr. Eng., 11, 53 (2019).

    Article  Google Scholar 

  35. C. T. Chiou, Partition and adsorption of organic contaminants in environmental systems. pp1-257. John Wiley & Sons, 2003.

  36. A. M. Willis, S. K. Smith, B. Meiser, P. A. James, M. L. Ballinger, D. M. Thomas, T. Yanes, and M.-A. Young, J. Genet. Couns., 30, 849 (2021).

    Article  PubMed  Google Scholar 

  37. J. Huang, P. S. F. Chan, V. Lok, X. Chen, H. Ding, Y. Jin, J. Yuan, X.-Q. Lao, Z.-J. Zheng, and M. C. S. Wong, Aging (Albany NY)., 13, 5748 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  38. A. M. Taylor, D. L. H. Chan, M. Tio, S. M. Patil, T. A. Traina, M. E. Robson, and M. Khasraw, Cochrane Database Syst Rev., 4, Cd011395 (2021).

    PubMed  Google Scholar 

  39. S. Gavas, S. Quazi, and T. M. Karpiński, Nanoscale. Res. Lett., 16, 173 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Y.-K. Huang, H.-R. Tian, M.-Z. Zhang, J.-L. He, J. Liu, and P.-H. Ni, J. Polym. Sci., 1–11 (2021).

  41. Sh. Husain, S. K. Verma, Hemlata, M. Azam, M. Sardar, Q. M. R. Haq, and T. Fatma, Mater. Sci. Eng. C., 122, 111888 (2021).

    Article  CAS  Google Scholar 

  42. Rosmalena, P. A. Widyastuti, F. Yazid, N. S. S. Ambarwati, and I. Ahmad, Pharmacogn Mag., 13, (2021).

  43. Y.-M. M. Park, N. Shivappa, J. Petimar, M. E. Hodgson, H. B Nichols, S. E. Steck, J. R. Hébert, and D. P. Sandler, Int. J. Cancer, 149, 615 (2021).

    Article  CAS  PubMed  Google Scholar 

  44. K. M. Owolabi, A. Shikongo, and A. Atangana, Fractal Fractional Derivative Operator Method on MCF-7 Cell Line Dynamics, in Methods of Mathematical Modelling and Computation for Complex Systems., 13, 319 (2022).

    Article  Google Scholar 

  45. C. Andriantsiferana, E. F. Mohamed, and H. Delmas, Environ. Technol., 35, 355 (2014).

    Article  CAS  PubMed  Google Scholar 

  46. R. A. El-Sayed, F. M. El-Demerdash, and M. A. El-Magd, Asian Pac. J. Trop. Biomed., 11, 254 (2021).

    Article  CAS  Google Scholar 

  47. M. Rani, A. Bhattacharjee, P. Singh, S. Basu, K. Das, K. Goswami, S. Pandey, D. Tripathi, and A. Kumar, Chapter 22 — Antimicrobial activities of different nanoparticles concerning to wastewater treatment, in Development in Wastewater Treatment Research and Processes, M. Shah, S. Rodriguez-Couto, and J. pp. 1–722. Biswas, Editors, Elsevier. (2022).

  48. S. Vihodceva, A. Šutka, M. Sihtmäe, M. Rosenberg, M. Otsus, I. Kurvet, K. Smits, L. Bikse, A. Kahru, and K. Kasemets, Nanomaterials (Basel)., 11, 652 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. R. G. Chaudhary, G. S. Bhusari, A. D. Tiple, A. R. Rai, S. R. Somkuwar, A. Potbhare, T. L. Lambat, P. P. Ingle, and A. A. Abdala, Curr. Pharm. Des., 25, 4013 (2019).

    Article  CAS  PubMed  Google Scholar 

  50. N. Qiu, L. Tian, X. Yan, H. Dong, M. Zhang, G. Han, and F. Zhou, HortSci., 1, 1 (2021).

    Google Scholar 

  51. L. Mei, X. Xitao, X. Renhao, and L. Zhili, Chin. J. Oceanol. Limnol., 24, 154 (2006).

    Article  Google Scholar 

  52. W. Wang, D. Li, X. Ding, Q. Zhao, J. Chen, K. Tian, Y. Qiu, and L. Lu, Toxicol. Lett., 279, 77 (2017).

    Article  CAS  PubMed  Google Scholar 

  53. A. Sharma, D. Kapoor, J. Wang, B. Shahzad, V. Kumar, A. Sh. Bali, Sh. Jasrotia, B. Zheng, H. Yuan, and D. Yan, Plants (Basel)., 9, 100 (2020).

    Article  CAS  PubMed Central  Google Scholar 

  54. J. Zhou, G. Gao, S. Zhang, H. Wang, L. Ke, J. Zhou, P. Rao, Q. Wang, and J. Li, Food Chem., 320, 126625 (2020).

    Article  CAS  PubMed  Google Scholar 

  55. H. A. Ngwa, M. Ay, H. Jin, V. Anantharam, A. Kanthasamy, and A. G. Kanthasamy, Adv. Neurobiol., 18, 287 (2017).

    Article  PubMed  Google Scholar 

  56. J. H. Park, B. M. Lee, and H. S. Kim, J. Toxicol. Environ. Health B: Crit Rev., 24, 95 (2021).

    Article  CAS  Google Scholar 

  57. D. Agay, R. A. Anderson, C. Sandre, N. A. Bryden, A. Alonso, A. M. Roussel, and Y. Chancerelle, Burns., 31, 366 (2005).

    Article  CAS  PubMed  Google Scholar 

  58. P. Mahawatte, K. Dissanayaka, and R. Hewamanna, J. Radioanal. Nucl. Chem., 270, 657 (2006).

    Article  CAS  Google Scholar 

  59. S. Taysi, F. Akcay, C. Uslu, Y. Dogru, and I. Gulcin, Biol. Trace Elem. Res., 91, 11–18 (2003).

    Article  CAS  PubMed  Google Scholar 

  60. T. Sokrateva, B. Roussev, M. Nashar, Y. Kiselova-Kaneva, G. Mihaylova, M. Todorova, M. Pasheva, O. Tasinov, N. Nazifova-Tasinova, D. Vankova, D. Ivanova, M. Radanova, B. Ts. Galunska, T. Vlaykova, D. Ivanova, Arch Physiol Biochem., 127, 327 (2021).

    Article  CAS  PubMed  Google Scholar 

  61. S.-M. Fendt and S. Y. Lunt, Cancer Cell., 37, 141 (2020).

    Article  CAS  PubMed  Google Scholar 

  62. L. Śliwka, K. Wiktorska, P. Suchocki, M. Milczarek, S. Mielczarek, K. Lubelska, T. Cierpiał, P. Łcyzwa, P. Kiełbasiński, A. Jaromin, A. Flis, and Z. Chilmonczyk, PloS one., 11, 0155772 (2016).

    Article  CAS  Google Scholar 

  63. C. Russo, M. Patanè, A. Russo, S. Stanzani, and R. Pellitteri, J. Mol. Neurosci., 71, 963 (2021).

    Article  CAS  PubMed  Google Scholar 

  64. D. Jeon, H. Kim, K. Nam, S. Oh, S.-H. Son, and I. Shin, Anticancer Res., 37, 6189 (2017).

    CAS  PubMed  Google Scholar 

  65. P. Babji and D. Roja Sri, J. Chem. Chem. Sci., 6, 616 (2016).

    Google Scholar 

  66. A. M. Evangelou, Crit. Rev. Oncol. Hematol., 42, 249 (2002).

    Article  PubMed  Google Scholar 

  67. Y. Feng, J.-W. Zeng, Q. Ma, Sh. Zhang, J. Tang, J.-F. Feng, J. Trace. Elem. Med. Biol., 62, 126629 (2020).

    Article  CAS  PubMed  Google Scholar 

  68. H. Xue, R. Qiao, L. Yan, S. Yang, Y. Liang, Y. Liu, Q. Xie, L. Cui, and B. Cao, Front Oncol., 11, 646534 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  69. D. C. Crans, L. Henry, G. Cardiff, and B. I. Posner, in Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic, De Gruyter, Berlin, 2019, Chap. 8, pp 203–230.

    Book  Google Scholar 

  70. Sh. Thakur, A. Tobey, and J. Klubo-Gwiezdzinska, Front Oncol., 9, 1092 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  71. Y. Feng, J. WeiZeng, Q. Ma, Sh. Zhang, J. Tang, and J.-F. Feng, J. Trace. Elem Med. Biol., 62, 126629 (2020).

    Article  CAS  PubMed  Google Scholar 

  72. H. Xue, R. Qiao, L. Yan, S. Yang, Y. Liang, Y. Liu, Q. Xie, L. Cui, and B. Cao, Front. Oncol., 11, 646534 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  73. V. Prabhu, V. Shridhar, and A. Choudhary, SN Appl. Sci., 1, 429 (2019).

    Article  CAS  Google Scholar 

  74. H. W. Kuo, S. F. Chen, Ch. Ch. Wu, D. R. Chen, and J. H. Lee, Biol. Trace. Elem. Res., 89, 1 (2002).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Materials Science and Engineering, Shahid Bahonar University of Kerman, Kerman, Iran

    Mehdi Firouzi, Maryam Ehteshamzadeh & Gholam Reza Khayati

  2. Department of Medical Laboratory Science, School of Paramedical, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Fakhredin Saba

  3. Department of Nanobiotechnology, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran

    Zhaleh Fakhri

Authors
  1. Mehdi Firouzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maryam Ehteshamzadeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fakhredin Saba
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gholam Reza Khayati
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zhaleh Fakhri
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fakhredin Saba.

Additional information

Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Acknowledgment: This investigation was supported by a grant from the Shahid Bahonar University of Kerman. The authors would like to thank all subjects who participated in this study either directly or indirectly.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Firouzi, M., Ehteshamzadeh, M., Saba, F. et al. Anti-Cancer Evaluation of Mineral Colloids Against MCF-7 Cell Lines: An Investigation Through Thermal Spring Water. Macromol. Res. 30, 406–414 (2022). https://doi.org/10.1007/s13233-022-0050-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13233-022-0050-8

Keywords

Search

Navigation