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Dynamic Protein Adsorption-Desorption Analysis of Contact Lenses in a Three-Dimensional-Printed Eye Model

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Abstract

Adsorption of secreted protein on contact lenses is a dynamic and complex behavior. To understand this behavior, we used three-dimensional (3D) printing technology to create an eye model that simulated the anterior segment of the actual human eyeball. In this model, the fluid inlet was connected to a syringe pump to mimic the rate of human tear secretion and the outlet was connected to an ultraviolet-visible (UV-Vis) spectrophotometer. The experimental results revealed that the symmetrical eye model with a 180° inlet-outlet angle was suitable for dynamic analysis of protein adsorption. In this model, protein adsorption was slow and desorption was rapid. The contact lens was soaked in poly(2-methacryloyloxyethyl phosphorylcholine-co-butyl methacrylate) (PMB) to confirm the anti-protein adsorption property of this polymer through dynamic adsorption and desorption eye model analysis.

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Authors and Affiliations

  1. R&D Center, Yung Sheng Optical Co., Daya District, Taichung, 42881, Taiwan

    Wan-Hsin Chang, Pei-Yi Liu, Dai-En Lin, Yuan-Ting Jiang & Chien-Ju Lu

  2. The Department of Chemistry, Tunghai University, Xitun District, Taichung, 40704, Taiwan

    Yuan-Hao Howard Hsu

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  1. Wan-Hsin Chang
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Correspondence to Chien-Ju Lu or Yuan-Hao Howard Hsu.

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Acknowledgment: This research was funded by Yung Sheng Optical Co., Ltd.

Supporting information: Information is available regarding the original data of the protein adsorption capacity of 3D-printing materials, and the dynamic adsorption curve of PMB coating contact lens. The materials are available via the Internet at http://www.springer.com/13233.

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Chang, WH., Liu, PY., Lin, DE. et al. Dynamic Protein Adsorption-Desorption Analysis of Contact Lenses in a Three-Dimensional-Printed Eye Model. Macromol. Res. 30, 6–15 (2022). https://doi.org/10.1007/s13233-022-0003-2

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  • DOI: https://doi.org/10.1007/s13233-022-0003-2

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