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Anti-coagulating hydroxyethyl starch blended with hyaluronic acid as a novel post-surgical adhesion barrier

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Abstract

Pharmacological and barrier-based approaches have been exploited for the treatment of post-surgical adhesion. In this study, anti-coagulating hydroxyethyl starch (HES) blended with hyaluronic acid (HA) was assessed as a novel post-surgical adhesion barrier in Sprague-Dawley (SD) rats to take advantage of both approaches. The HES/HA blend solution effectively reduced the adhesion area to 6.5% of the control, which might be due to the inhibited blood coagulation by HES as well as highly effective barrier properties of hygroscopic high molecular weight HA. Histological analysis showed that the HES/HA blend solutions effectively protected the smooth muscle cells and skeletal muscle cells from muscle degeneration by adhesion in the abdominal walls of SD rats.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, Pohang University of Science and Technology, Gyungbuk, 790-784, Korea

    Jung Kyu Park, Junseok Yeom & Sei Kwang Hahn

  2. Biotechnology Department, Central Research Institute, Shinpoong Pharmaceutical Co., Gyeonggi, 425-100, Korea

    Eui Jin Hwang, Jang Sik Shin & Il Hwan Cho

  3. School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea

    Suk Ho Bhang & Byung-Soo Kim

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  1. Jung Kyu Park
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  2. Junseok Yeom
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  3. Sei Kwang Hahn
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  4. Eui Jin Hwang
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  5. Jang Sik Shin
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  6. Il Hwan Cho
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  7. Suk Ho Bhang
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  8. Byung-Soo Kim
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Correspondence to Sei Kwang Hahn.

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Park, J.K., Yeom, J., Hahn, S.K. et al. Anti-coagulating hydroxyethyl starch blended with hyaluronic acid as a novel post-surgical adhesion barrier. Macromol. Res. 18, 1076–1080 (2010). https://doi.org/10.1007/s13233-010-1103-y

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  • DOI: https://doi.org/10.1007/s13233-010-1103-y

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