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Inhibin B Secreting Ovarian Fibroma

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Abstract

Background

Nearly 90% of all the hormone-producing ovarian tumours are sex cord-stromal tumours (SCSTs). The Ovarian fibroma is a hormonally inactive variant of SCST. It is composed of spindle, oval, round cells producing collagen and accounts for approximately 4% of all ovarian neoplasms. Amongst the other SCSTs, Inhibin B is an important tumour marker. It is a heterodimeric glycoprotein hormone that is secreted primarily by the granulosa cells of the developing follicles. High levels of Inhibin-B can hamper follicular recruitment, leading to amenorrhea in a reproductive age woman.

Finding

In this case report, we describe a rare case of a reproductive age female presenting with secondary amenorrhea, having an Ovarian Fibroma, producing massive amounts of Inhibin B.

Significance

Although some pathological variants of ovarian fibromas like cyst-adeno-fibroma and ovarian fibro-thecoma are known to secrete inhibin B, benign /pure ovarian fibromas rarely do so.

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References

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Funding

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, AIIMS Jodhpur, Jodhpur, Rajasthan, 342005, India

    Garima Yadav & Ishita Aggarwal

  2. Department of Pathology, AIIMS Jodhpur, Jodhpur, India

    Aasma Nalwa

  3. Department of Diagnostic and Interventional Radiology, AIIMS Jodhpur, Jodhpur, India

    Binit Sureka

Authors
  1. Garima Yadav
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  2. Ishita Aggarwal
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  3. Aasma Nalwa
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  4. Binit Sureka
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Corresponding author

Correspondence to Ishita Aggarwal.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed during the treatment of the concerned patient were in accordance with the ethical standards of AIIMS.

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Informed consent was obtained from the patient.

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Dr. Garima Yadav is a MBBS, MS (Obstetrics & Gynaecology) Associate Professor at the Department of Obstetrics and Gynaecology, AIIMS Jodhpur, 342,005 Rajasthan India; Dr. Ishita Aggarwal is a MBBS, Junior Resident in the Department of Obstetrics and Gynaecology AIIMS Jodhpur, 342,005 Rajasthan India; Dr. Aasma Nalwa is a MBBS M.D. Pathology Assistant Professor Department of Pathology AIIMS Jodhpur, 342,005 Rajasthan India; Dr. Binit Sureka is MBBS M.D. Radiology Assistant Professor Department of diagnostic and interventional radiology AIIMS Jodhpur, 342,005 Rajasthan India.

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Yadav, G., Aggarwal, I., Nalwa, A. et al. Inhibin B Secreting Ovarian Fibroma. J Obstet Gynecol India 72, 356–359 (2022). https://doi.org/10.1007/s13224-021-01601-y

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  • DOI: https://doi.org/10.1007/s13224-021-01601-y

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