Abstract
Apoptosis-inducing factor 1 (AIF1) was originally considered to induce apoptosis in yeast through a partially caspase-dependent pathway. In our research work, we demonstrated that aif1p could also inhibit fluconazole resistance in yeast. Several ABC transporters such as PDR5, PDR10 and HXT11 were upregulated in an aif1 mutant. A rhodamine 6 G (R6G) efflux study demonstrated increased extrusion of R6G through efflux pumps in the aif1 mutant. Therefore, we concluded that aif1p may inhibit the development of FLC resistance in yeast via some ABC transporters induction.
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Kong, F., Liu, X., Huang, N. et al. Aif1p inhibits development of fluconazole resistance in yeast. Ann Microbiol 62, 1461–1466 (2012). https://doi.org/10.1007/s13213-011-0399-y
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DOI: https://doi.org/10.1007/s13213-011-0399-y