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Hepatoprotective and nephroprotective effects of Sedum adenotrichum in paracetamol-induced hepatotoxicity in rabbits

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Abstract

Sedum adenotrichum (SA) has been traditionally used against various ailments due to the presence of several important phenolic compounds. This study provides a scientific basis for the hepatoprotective and nephroprotective potentials of Sedum adenotrichum in paracetamol-induced toxicity in rabbits. Methanolic extract of Sedum adenotrichum along with paracetamol was administered orally to rabbits alone or in combination with paracetamol for 2 weeks. Results showed that paracetamol-induced toxicity was correlated with a significant change in biochemical, hematological parameters, and loss in body weight of rabbits, and the curative effect of SA methanolic extract was found. Liver and kidney histological studies showed significant induced toxicity of paracetamol and correspondence restoration power of SA methanolic extract. The levels of reduced glutathione, radical scavenging activity, and lipid peroxidation in the liver were restored to normal by the methanolic extract of SA. This study confirmed the protective effect of SA methanolic extract against hepatotoxicity and nephrotoxicity caused by paracetamol. Biochemical analysis of the methanolic extract of SA confirmed the presence of bioactive phenolic compounds which have hepatic and nephroprotective potentials.

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Acknowledgements

Department of Biochemistry, University of Malakand is highly acknowledged for providing space facility for conducting the study.

Funding

This was a self-funded study and no funding agency helped us financially.

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Authors and Affiliations

  1. Department of Zoology, Islamia College University, Peshawar, Khyber Pakhtunkhwa, 25000, Pakistan

    Dil Naz, Aziz ur Rahman & Ali Muhammad

  2. Department of Biochemistry, University of Malakand, Chakdara, Khyber Pakhtunkhwa, 18800, Pakistan

    Dil Naz, Alam Zeb & Nausheen Nazir

  3. Department of Zoology, Government College University, Lahore, 54000, Pakistan

    Rehan Ullah

Authors
  1. Dil Naz
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  2. Alam Zeb
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  3. Nausheen Nazir
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  4. Rehan Ullah
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  5. Aziz ur Rahman
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  6. Ali Muhammad
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Contributions

DN, AZ, RU: experimentation, writing–review and editing. Alam Zeb, Ali Muhammad: supervision, funding acquisition. DN: writing–original draft, formal analysis, investigation. AZ, RU: methodology, conceptualization. DN, NN: visualization, conceptualization, validation.

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Correspondence to Alam Zeb.

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It is declared that the author(s) have no competing interests.

Ethical approval

Ethical Committee of Pharmacy Department approved this protocol under ethical clearance (E-SA-11-2009) act “Animal Bye-Laws 2008, Scientific Procedures Issue-I of University of Malakand”.

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Naz, D., Zeb, A., Nazir, N. et al. Hepatoprotective and nephroprotective effects of Sedum adenotrichum in paracetamol-induced hepatotoxicity in rabbits. 3 Biotech 13, 217 (2023). https://doi.org/10.1007/s13205-023-03641-9

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  • DOI: https://doi.org/10.1007/s13205-023-03641-9

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