Abstract
Magnetic nanoparticles (MNP) and silicon-decorated magnetic nanoparticles (SMNP) have been the object of interest in numerous industry fields as diverse as information storage, diagnostics and imaging, and water treatment thanks to their magnetic properties, which confer them the ability to navigate remotely to a specific location, retrieve material, and vibrate without harmful radiation. However, like all chemical agents, the nanoparticles require pinpoint regulations to ensure proper handling, use, and disposal once their use is finished. The human body's exposition can lead to unknown effects once these particles reach internal structures, like the vascular system. The results show that concentrations of MNP (1–1000 μg/ml) induced alteration on the cardiovascular physiology, on the cardiac contractility, and in the perfusion pressure. Parameters that also were associated with the alteration on nitric oxide (NO) levels, a free radical which regulate the vascular tone, effects displayed from the first administration of the lowest concentration derived from a sustained constriction, which also induced inhibition of the relaxation by the vasoactive substance acetylcholine (ACh), and the blockage of norepinephrine (NE), respectively.
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Acknowledgements
JRVO thanks CONACyT for the scholarship granted, and Francisco Torres de la Rosa for technical assistance. The authors also thank the Engineering Faculty-UAQ for the financial support granted through the Attention to national problems fund FI-UAQ-2021, to the Universidad Autónoma de Querétaro through the FONDEC-UAQ-2021fund, to the Universidad Autónoma de San Luis Potosi through the research support fund C20-FAI-10.22.22 and SINANOTOX-PN-2017-01-4710-CONACyT.
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KE and CG conceived and designed the experiments; JRV-O, HNB, and KE characterized the samples by XRD, Raman, PZ, and magnetic techniques; JRV-O. Synthesized the samples, collected, and analyzed all the data. All authors discussed the experiment results and contributed to the writing of the paper. All authors have read and agreed to the published version of the manuscript. Conceptualization, KE and CG; Data curation, JRV-O; Formal analysis, JRV-O, HNB, CG and KE; Funding acquisition, CG and KE; Investigation, JRV-O, HNB, CG, and KE; Methodology, JRV-O; Project administration, KE; Resources, CG and KE; Validation, HNB, CG and KE; Writing—original draft, JRV-O; Writing—review and editing, HNB, CG, and KE.
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The experiments were conducted following the Official Mexican Standard NOM-062-ZOO-1999 based on the Guide for the Care and Use of Animals of Laboratory of the National Institute of Health, submitted to the university's bioethics committee, and approved with identification number CEAIFI-196-2018-TP, CEID2014033 and CEID2020-03.
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Vargas-Ortíz, J.R., Böhnel, H.N., Gonzalez, C. et al. Magnetic nanoparticle behavior evaluation on cardiac tissue contractility through Langendorff rat heart technique as a nanotoxicology parameter. Appl Nanosci 11, 2383–2396 (2021). https://doi.org/10.1007/s13204-021-02031-y
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DOI: https://doi.org/10.1007/s13204-021-02031-y