Abstract
Ag nanorod arrays/dielectrics/mirror-structured multilayer thin films are well-known, sensitive surface-enhanced Raman scattering (SERS) substrates that enhance the Raman scattering cross section by the interference of light. However, it is difficult to extract biomarkers directly from human skin using these solid substrates. To overcome this problem, we propose a multilayer thin-film flake dispersion gel by centrifugal mixing of the multilayer thin film and hydroxyethyl cellulose (HEC) gel. The multilayer thin film was prepared by serial bideposition using the dynamic oblique angle deposition technique. The mixing process was optimized to obtain flakes of ~ 10 μm so that the optical properties of the multilayer film can be preserved, and there is no risk of adverse effects on humans. The SERS characteristics of the flakes dispersion gel were tested using 4, 4′-bipyridine (BPY). The BPY molecules diffused through the highly porous gel within seconds, producing significant SERS signals. The multilayer thin-film flakes dispersion gel showed a SERS signal approximately 20 times better than the gel-dispersed Ag nanorod arrays without a multilayer film structure. These SERS active flakes dispersion gel can be used directly on the skin surface to collect body fluids from sweat, for biomarker sensing.
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Acknowledgements
The authors thank Dr. Kosuke Ishikawa of Kyoto University for assisting us with the SEM observations.
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This work was supported by JST COI Grant Number JPMJCE1307.
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Kumar, S., Kanagawa, M., Namura, K. et al. Multilayer thin-film flake dispersion gel for surface-enhanced Raman spectroscopy. Appl Nanosci 13, 155–163 (2023). https://doi.org/10.1007/s13204-020-01562-0
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DOI: https://doi.org/10.1007/s13204-020-01562-0