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Antioxidation and antiglycation of Fagopyrum tataricum ethanol extract

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Abstract

Fagopyrum tataricum is used for the treatment of type 2 diabetes mellitus in Taiwan. The aim of this study was to evaluate the inhibitory effects of 75 % ethanol extract of buckwheat (EEB) and rutin on carbohydrate-metabolized enzymes, including α-amylase and α-glucosidase, which are related to hyperglycemia. The rutin dosage (40 μg/mL) was equivalent to that of EEB (200 μg/mL). In addition, the antioxidant and antiglycation activities of EEB and rutin were investigated. Results showed that both EEB and rutin exerted free radical (DPPH and ABTS) scavenging activity. They also attenuated protein glycation to lower the generation of advanced glycation end-products (AGEs) through the suppression of fructosamine and α-dicarbonyl compounds. Moreover, EEB and rutin also inhibited α-amylase and α-glucosidase activity. Taken together, these findings suggest that EEB and rutin may reduce oxidative stress, AGEs formation, and carbohydrate-metabolized enzymes hence EEB may use as protection agent in diabetic patients.

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Authors and Affiliations

  1. Department of Food Science, College of Life Science, National Chiayi University, Chiayi, Taiwan

    Chia-Chen Lee & Bao-Hong Lee

  2. Department of Food Science, National Quemoy University, No.1, Daxue Rd., Jinning Township, Kinmen County, 892, Taiwan

    Ying-Jang Lai

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  1. Chia-Chen Lee
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  2. Bao-Hong Lee
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Correspondence to Ying-Jang Lai.

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Lee, CC., Lee, BH. & Lai, YJ. Antioxidation and antiglycation of Fagopyrum tataricum ethanol extract. J Food Sci Technol 52, 1110–1116 (2015). https://doi.org/10.1007/s13197-013-1098-4

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  • DOI: https://doi.org/10.1007/s13197-013-1098-4

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