Abstract
The emerging radionanomedicine has multifunctional and theranostic purposes. For these purposes, radionanomedicine should achieve the efficient and specific delivery of therapeutic agents by multifunctional characteristics, using low amounts of nanomaterials in vivo. Recent research on radiolabeled micelle-encapsulated nanomaterials has been made on the their efficacy and safety using a one-step surface modification method (Jeong’s method). This one-step multifunctional approach to the nanoparticle can be the important challenge in producing effective nanoplatforms for cancer imaging and therapy.
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References
Muthu MS, Wilson B. Multifunctional radionanomedicine: a novel nanoplatform for cancer imaging and therapy. Nanomedicine (Lond). 2010;5:169–71.
Lee DS, Im H-J, Lee Y-S. Radionanomedicine: widened perspectives of molecular theragnosis. Nanomedicine. 2015;11:795-810
Muthu MS, Singh S. Targeted nanomedicines: effective treatment modalities for cancer, AIDS and brain disorders. 2009.
Muthu MS, Rawat MK, Mishra A, Singh S. PLGA nanoparticle formulations of risperidone: preparation and neuropharmacological evaluation. Nanomedicine. 2009;5:323–33.
Sumer B, Gao J. Theranostic nanomedicine for cancer. Nanomedicine. 2008;3:137–40.
Ting G, Chang C-H, Wang H-E. Cancer nanotargeted radiopharmaceuticals for tumor imaging and therapy. Anticancer Res. 2009;29:4107–18.
Velikyan I. Prospective of 68Ga-radiopharmaceutical development. Theranostics. 2014;4:47.
Niccoli Asabella A, Cascini GL, Altini C, Paparella D, Notaristefano A, Rubini G. The copper radioisotopes: a systematic review with special interest to 64Cu. BioMed Res Int. 2014;2014:786463.
Anderson CJ, Ferdani R. Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research. Cancer Biother Radiopharm. 2009;24:379–93.
Fischer G, Seibold U, Schirrmacher R, Wängler B, Wängler C. 89Zr, a radiometal nuclide with high potential for molecular imaging with PET: chemistry, applications and remaining challenges. Molecules. 2013;18:6469–90.
Kam B, Teunissen J, Krenning E, et al. Lutetium-labelled peptides for therapy of neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2012;39:103–12.
Sainz-Esteban A, Prasad V, Schuchardt C, Zachert C, Carril JM, Baum RP. Comparison of sequential planar 177Lu-DOTA-TATE dosimetry scans with 68Ga-DOTA-TATE PET/CT images in patients with metastasized neuroendocrine tumours undergoing peptide receptor radionuclide therapy. Eur J Nucl Med Mol Imaging. 2012;39:501–11.
Goffredo V, Paradiso A, Ranieri G, Gadaleta CD. Yttrium-90 (90 Y) in the principal radionuclide therapies: An efficacy correlation between peptide receptor radionuclide therapy, radioimmunotherapy and transarterial radioembolization therapy. Ten years of experience (1999–2009). Crit Rev Oncol Hematol. 2011;80:393–410.
Jeong JM, Chung J-K. Therapy with 188Re-labeled radiopharmaceuticals: an overview of promising results from initial clinical trials. Cancer Biother Radiopharm. 2003;18:707–17.
Hong H, Zhang Y, Sun J, Cai W. Molecular imaging and therapy of cancer with radiolabeled nanoparticles. Nano Today. 2009;4:399–413.
Goel S, Chen F, Ehlerding EB, Cai W. Intrinsically radiolabeled nanoparticles: an emerging paradigm. Small. 2014;10:3825–30.
Sun M, Hoffman D, Sundaresan G, Yang L, Lamichhane N, Zweit J. Synthesis and characterization of intrinsically radiolabeled quantum dots for bimodal detection. Am J Nucl Med Mol Imaging. 2012;2:122.
Xing Y, Zhao J, Conti PS, Chen K. Radiolabeled nanoparticles for multimodality tumor imaging. Theranostics. 2014;4:290.
Wadas TJ, Wong EH, Weisman GR, Anderson CJ. Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease. Chem Rev. 2010;110:2858–902.
Susumu K, Uyeda HT, Medintz IL, Pons T, Delehanty JB, Mattoussi H. Enhancing the stability and biological functionalities of quantum dots via compact multifunctional ligands. J Am Chem Soc. 2007;129:13987–96.
Åkerman ME, Chan WC, Laakkonen P, Bhatia SN, Ruoslahti E. Nanocrystal targeting in vivo. Proc Natl Acad Sci USA. 2002;99:12617–21.
Lee YK, Jeong JM, Hoigebazar L, et al. Nanoparticles modified by encapsulation of ligands with a long alkyl chain to affect multispecific and multimodal imaging. J Nucl Med. 2012;53:1462–70.
Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, Libchaber A. In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science. 2002;298:1759–62.
Carion O, Mahler B, Pons T, Dubertret B. Synthesis, encapsulation, purification and coupling of single quantum dots in phospholipid micelles for their use in cellular and in vivo imaging. Nat Protoc. 2007;2:2383–90.
Samanta A, Maiti KK, Soh KS, et al. Ultrasensitive near-infrared Raman reporters for SERS-based in vivo cancer detection. Angew Chem Int Ed Engl. 2011;50:6089–92.
Jun BH, Hwang DW, Jung HS, et al. Ultrasensitive, biocompatible, quantum-dot-embedded silica nanoparticles for bioimaging. Adv Funct Mater. 2012;22:1843–9.
Fan H, Yang K, Boye DM, et al. Self-assembly of ordered, robust, three-dimensional gold nanocrystal/silica arrays. Science. 2004;304:567–71.
Wu H, Zhu H, Zhuang J, Yang S, Liu C, Cao YC. Water-soluble nanocrystals through dual-interaction ligands. Angew Chem Int Ed. 2008;47:3730–4.
Yang BY, Moon SH, Seelam SR, et al. Development of a multimodal imaging probe by encapsulating iron oxide nanoparticles with functionalized amphiphiles for lymph node imaging. Nanomedicine (Lond). 2015;10:1899-910.
Hrkach J, Von Hoff D, Ali MM, et al. Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile. Sci Transl Med. 2012;4:128ra39.
Danhier F, Vroman B, Lecouturier N, et al. Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with paclitaxel. J Control Release. 2009;140:166–73.
Acknowledgments
This study was funded by the National Research Foundation of Korea (2014M2A2A7045043 and 2012R1A1A2008799).
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Yung-Sang Lee, Yong-il Kim, and Dong Soo Lee declare that they have no conflicts of interest.
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This article does not contain any studies with human participants or animals performed by any of the authors. The manuscript has not been published before or is not under consideration for publication anywhere else and has been approved by all co-authors.
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Lee, YS., Kim, Yi. & Lee, D.S. Future Perspectives of Radionanomedicine Using the Novel Micelle-Encapsulation Method for Surface Modification. Nucl Med Mol Imaging 49, 170–173 (2015). https://doi.org/10.1007/s13139-015-0358-9
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DOI: https://doi.org/10.1007/s13139-015-0358-9