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Cholecystectomy as a risk factor for metabolic dysfunction-associated fatty liver disease: unveiling the metabolic and chronobiologic clues behind the bile acid enterohepatic circulation

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Abstract

Metabolic dysfunction-associated fatty liver disease (MAFLD) is highly prevalent worldwide. Recent clinical and experimental studies have addressed the association between cholecystectomy and MAFLD, confirming that cholecystectomy is an independent risk factor for MAFLD. In this review, we describe the epidemiologic evidence that links cholecystectomy to MAFLD, and discuss the possible mechanisms behind these connections, in order to unveil the metabolic and chronobiologic signals conveyed by the waves of the bile acid enterohepatic circulation.

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Funding

This work was supported by the Natural Science Foundation of China (grant numbers: 81500483 and 81670580).

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Authors and Affiliations

  1. Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, No. 39, Hua xiang Road, Tiexi District, Shenyang, 110022, Liaoning Province, China

    Li Qi

  2. Innovation Institute of China Medical University, No. 77, Pu He Road, Shenbeixin District, Shenyang, 110004, Liaoning Province, China

    Wanlin Dai

  3. Department of General Surgery, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Heping District, Shenyang, 110004, Liaoning Province, China

    Jing Kong, Yu Tian & Yongsheng Chen

Authors
  1. Li Qi
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  2. Wanlin Dai
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  3. Jing Kong
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  4. Yu Tian
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  5. Yongsheng Chen
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Corresponding author

Correspondence to Yongsheng Chen.

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Key points

1. The gallbladder provides rhythmic release of concentrated bile acids.

2. Bile acids are endocrine and chronobiologic signaling molecules.

3. Bile acid enterohepatic circulation conveys important chronobiologic information.

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Qi, L., Dai, W., Kong, J. et al. Cholecystectomy as a risk factor for metabolic dysfunction-associated fatty liver disease: unveiling the metabolic and chronobiologic clues behind the bile acid enterohepatic circulation. J Physiol Biochem 77, 497–510 (2021). https://doi.org/10.1007/s13105-020-00782-w

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  • DOI: https://doi.org/10.1007/s13105-020-00782-w

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