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Disease of mRNA Regulation: Relevance for Ischemic Brain Injury

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Abstract

In this mini-review we give an overview of the role of mRNA-binding proteins and their associated messenger ribonucleoprotein complexes (mRNPs) in several disease states, and bring this information to bear on the pathophysiology of brain ischemia. One conclusion reached is that mRNPs may play a causal role in proteotoxicity instead of being merely passive targets. Ischemia therapies targeting mRNPs have advantages over targeting single pathways, but the behavior of mRNPs needs to be considered in the design of therapies.

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Funding

This work was supported by NIH Grants No. NS081347 (D.J.D.).

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  1. Department of Physiology, and the Center for Molecular Medicine and Genetics, Wayne State University, 4116 Scott Hall, 540 E. Canfield, Detroit, MI, 48201, USA

    Donald J. DeGracia

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Correspondence to Donald J. DeGracia.

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The author declares no conflict of interest. The present work is a review article and does not directly involve animal or human research.

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DeGracia, D.J. Disease of mRNA Regulation: Relevance for Ischemic Brain Injury. Transl. Stroke Res. 9, 251–257 (2018). https://doi.org/10.1007/s12975-017-0586-7

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