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Translational MR Neuroimaging of Stroke and Recovery

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Abstract

Multiparametric magnetic resonance imaging (MRI) has become a critical clinical tool for diagnosing focal ischemic stroke severity, staging treatment, and predicting outcome. Imaging during the acute phase focuses on tissue viability in the stroke vicinity, while imaging during recovery requires the evaluation of distributed structural and functional connectivity. Preclinical MRI of experimental stroke models provides validation of non-invasive biomarkers in terms of cellular and molecular mechanisms, while also providing a translational platform for evaluation of prospective therapies. This brief review of translational stroke imaging discusses the acute to chronic imaging transition, the principles underlying common MRI methods employed in stroke research, and the experimental results obtained by clinical and preclinical imaging to determine tissue viability, vascular remodeling, structural connectivity of major white matter tracts, and functional connectivity using task-based and resting-state fMRI during the stroke recovery process.

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Authors and Affiliations

  1. Neuroprotection Research Laboratory, Massachusetts General Hospital, Charlestown, MA, USA

    Emiri T. Mandeville

  2. Neurovascular Research Laboratory, Massachusetts General Hospital, Charlestown, MA, USA

    Cenk Ayata & Yi Zheng

  3. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA

    Joseph B. Mandeville

  4. Department of Radiology, Massachusetts General Hospital, Bldg 149 13th Street, Charlestown, MA, 02129, USA

    Emiri T. Mandeville, Cenk Ayata, Yi Zheng & Joseph B. Mandeville

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  1. Emiri T. Mandeville
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  2. Cenk Ayata
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  4. Joseph B. Mandeville
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Correspondence to Emiri T. Mandeville.

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This work was funded in part by a grant from the National Institutes of Health (P01NS055104).

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Mandeville, E.T., Ayata, C., Zheng, Y. et al. Translational MR Neuroimaging of Stroke and Recovery. Transl. Stroke Res. 8, 22–32 (2017). https://doi.org/10.1007/s12975-016-0497-z

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