Abstract
With the advent of time-dependent thrombolytic therapy for ischemic stroke, it has become increasingly important to differentiate transient ischemic attack (TIA) from minor stroke patients after symptom onset quickly. This study investigated the difference between TIA and minor stroke based on age, blood pressure, clinical features, duration of TIA, presence of diabetes, ABCD2 score, digital subtraction angiography (DSA) and blood lipids. One hundred seventy-one patients with clinical manifestations as transient neurological deficits in Nanjing Drum Tower Hospital were studied retrospectively. All patients were evaluated by ABCD2 score, blood lipid test, fibrinogen, and Holter electrocardiograph and DSA on admission. Patients were categorized into TIA group or minor stroke group according to CT and MRI scan 24 h within symptom onset. The study suggested that minor stroke patients were more likely to have a higher ABCD2 score (odds ratio (OR) 2.060; 95 % confidence interval (CI) 1.293–3.264). Receiver-operating characteristic curves identified ABCD2 score >4 as the optimal cut-off for minor stroke diagnosis. Total serum cholesterol seemed a better diagnostic indicator to discriminate minor stroke from TIA (OR 4.815; 95 % CI 0.946–1.654) than other blood lipids in simple logistic regression, but not valuable for the differentiation between TIA and minor stroke in multivariate logistic regression. Higher severity of intracranial internal carotid stenosis, especially >90 %, were more likely to have minor stroke, but was not a reliable diagnostic indicator (P > 0.05). ABCD2 could help clinicians to differentiate possible TIA from minor stroke at hospital admission while blood lipid parameters and artery stenosis location offer limited help.
Similar content being viewed by others
References
Sheehan OC et al. Diagnostic usefulness of the ABCD2 score to distinguish transient ischemic attack and minor ischemic stroke from noncerebrovascular events: the North Dublin TIA Study. Stroke. 2009;40(11):3449–54.
von Weitzel-Mudersbach P et al. Transient ischemic attack and minor stroke are the most common manifestations of acute cerebrovascular disease: a prospective, population-based study—the Aarhus TIA study. Neuroepidemiology. 2013;40(1):50–5.
Kate M et al. Early risk and predictors of cerebrovascular and cardiovascular events in transient ischemic attack and minor ischemic stroke. Neurol India. 2012;60(2):165–7.
Furie KL et al. Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the American heart association/American stroke association. Stroke. 2011;42(1):227–76.
Easton JD et al. Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists. Stroke. 2009;40(6):2276–93.
Adams Jr HP et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Circulation. 2007;115(20):e478–534.
Park TH et al. Validation of minor stroke definitions for thrombolysis decision making. J Stroke Cerebrovasc Dis. 2013;22(4):482–90.
Garcia-Garcia J et al. Is it justified to exclude patients with minor stroke from intravenous thrombolysis? Int J Stroke. 2013;8(3):E4.
Stecksen A et al. Thrombolytic therapy rates and stroke severity: an analysis of data from the Swedish stroke register (Riks-Stroke) 2007–2010. Stroke. 2012;43(2):536–8.
Kruetzelmann A et al. Thrombolysis targeting MRI defined tissue at risk in minor stroke. J Neurol Neurosurg Psychiatry. 2009;80(10):1156–8.
Jagoda A, Chan YF. Transient ischemic attack overview: defining the challenges for improving outcomes. Ann Emerg Med. 2008;52(2):S3–6.
Kamel H, Fahimi J, Govindarajan P, Navi BB. Nationwide patterns of hospitalization after transient ischemic attack. J Stroke Cerebrovasc Dis. 2012; In press.
Coull AJ et al. Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services. BMJ. 2004;328(7435):326.
Samuels OB et al. A standardized method for measuring intracranial arterial stenosis. AJNR Am J Neuroradiol. 2000;21(4):643–6.
Smith EE et al. Outcomes in mild or rapidly improving stroke not treated with intravenous recombinant tissue-type plasminogen activator: findings from get with The Guidelines-Stroke. Stroke. 2011;42(11):3110–5.
Breuer L et al. Off-label thrombolysis for acute ischemic stroke: rate, clinical outcome and safety are influenced by the definition of ‘minor stroke’. Cerebrovasc Dis. 2011;32(2):177–85.
Altieri M et al. Depression after minor stroke: prevalence and predictors. Eur J Neurol. 2012;19(3):517–21.
Hachinski V. The 2005 Thomas Willis Lecture: stroke and vascular cognitive impairment: a transdisciplinary, translational and transactional approach. Stroke. 2007;38(4):1396.
Sanders LM et al. Performance of the ABCD2 score for stroke risk post TIA: meta-analysis and probability modeling. Neurology. 2012;79(10):971–80.
Ay H et al. Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2009;40(1):181–6.
Adeoye O et al. How much would performing diffusion-weighted imaging for all transient ischemic attacks increase MRI utilization? Stroke. 2010;41(10):2218–22.
Selvarajah JR et al. Prognosis in patients with transient ischaemic attack (TIA) and minor stroke attending TIA services in the North West of England: the NORTHSTAR Study. J Neurol Neurosurg Psychiatry. 2008;79(1):38–43.
Yusuf S et al. Telmisartan to prevent recurrent stroke and cardiovascular events. N Engl J Med. 2008;359(12):1225–37.
Smith EE et al. Frequency and determinants of lipid testing in ischemic stroke and transient ischemic attack: findings from get with the guidelines-stroke. Stroke. 2010;41(2):232–8.
Uddin MJ et al. Association of lipid profile with ischemic stroke. Mymensingh Med J. 2009;18(2):131–5.
Shahar E et al. Plasma lipid profile and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study. Stroke. 2003;34(3):623–31.
Sillesen H et al. Atorvastatin reduces the risk of cardiovascular events in patients with carotid atherosclerosis: a secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. Stroke. 2008;39(12):3297–302.
Pan SL et al. Is higher serum total cholesterol level associated with better long-term functional outcomes after noncardioembolic ischemic stroke? Arch Phys Med Rehabil. 2010;91(6):913–8.
Kasner SE et al. Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis. Circulation. 2006;113(4):555–63.
Swiercz M et al. Narrowing of the middle cerebral artery: artificial intelligence methods and comparison of transcranial color coded duplex sonography with conventional TCD. Ultrasound Med Biol. 2010;36(1):17–28.
Coutts SB et al. CT/CT angiography and MRI findings predict recurrent stroke after transient ischemic attack and minor stroke: results of the prospective CATCH study. Stroke. 2012;43(4):1013–7.
Acknowledgments
This study was supported by the National Natural Science Foundation of China (81230026, 81171085, 81200896, and 81200897), the Medical Leading Talent and Innovation Team Project of Jiangsu Province (LJ201101).
Conflict of interest
There are no conflicts of interest for any of the authors relating to this manuscript.
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Zhao, H., Li, Q., Lu, M. et al. ABCD2 Score May Discriminate Minor Stroke from TIA on Patient Admission. Transl. Stroke Res. 5, 128–135 (2014). https://doi.org/10.1007/s12975-013-0286-x
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12975-013-0286-x