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Predictors of early restenosis after intracardiac echocardiography guided antegrade balloon aortic valvuloplasty in high-risk or inoperable patients

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Abstract

Antegrade balloon aortic valvuloplasty (BAV) may be more effective than retrograde BAV. However, early restenosis is found inconstantly within three months after BAV. To evaluate the factor of ER after intracardiac echocardiogram (ICE) guided Antegrade BAV, fifty patients with severe aortic stenosis (AS) underwent BAV procedures with ICE. ER was defined as mean aortic valve pressure gradient (PG) >40 mmHg. During one-year follow-up period, 6 patients died and 2 patients underwent aortic valve replacement. ER was present in 13 patients (26%) at three months after BAV. Procedural, clinical, and hemodynamic data were collected. The mean age of the patient population was 85.4 ± 7.6 years; the mean STS score and EuroSCORE were 7.8 ± 1.1 and 14.6 ± 4.1, respectively. The mean aortic valve PG decreased from 63.4 ± 19.8 to 28.5 ± 10.1 mmHg (p < 0.0001). Baseline characteristics were similar between the two groups. There is no significant difference of mean aortic valve PG immediate after BAV(ER; 29 ± 8.8 mmHg, nonER; 21 ± 6.1 mmHg, p = ns). Univariate analysis showed patients with ER group had significantly higher rate of left ventricular hypertrophy, pulmonary hypertension, and high mean aortic valve PG at admission. Multivariate analysis revealed high mean aortic valve PG at admission as independent predictors of ER. Antegrade BAV may be effective for severe AS. Left ventricular hypertrophy, pulmonary hypertension and high mean PG were predictor of early restenosis. Early intervention should be considered for these patients.

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Authors and Affiliations

  1. Division of Cardiology, Tokushima Red Cross Hospital, Irinokuchi103, Komatsushima-cho, Komatsushima, 773-8502, Japan

    Shinobu Hosokawa, Yoshikazu Hiasa, Akiho Seno, Tatuo Yasuoka, Tomoko Izumi & Riyo Ogura

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  1. Shinobu Hosokawa
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  2. Yoshikazu Hiasa
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  3. Akiho Seno
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  4. Tatuo Yasuoka
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  5. Tomoko Izumi
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  6. Riyo Ogura
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Correspondence to Shinobu Hosokawa.

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This study complied with the Declaration of Helsinki in regard to investigation in humans and was approved by the institutional ethics committees at Tokushima red cross Hospital. There was no industry involvement in the design, conduct, financial support, or analysis of this study.

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Hosokawa, S., Hiasa, Y., Seno, A. et al. Predictors of early restenosis after intracardiac echocardiography guided antegrade balloon aortic valvuloplasty in high-risk or inoperable patients. Cardiovasc Interv and Ther 33, 109–115 (2018). https://doi.org/10.1007/s12928-016-0451-8

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  • DOI: https://doi.org/10.1007/s12928-016-0451-8

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