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Catheter closure of patent foramen ovale in patients with cryptogenic cerebrovascular accidents: initial experiences in Japan

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Abstract

Although numerous studies have shown an association between a patent foramen ovale (PFO) and cryptogenic cerebrovascular accidents (CVA), there has been no definitive control study that demonstrated the benefit of percutaneous device closure of a PFO compared to medical therapy in patients with CVA. Additionally, few clinical data exist for Japanese patients in this field. We demonstrate the initial experiences in catheter closure of a PFO as secondary prevention of CVA in Japan. Catheter closure of a PFO was attempted in 7 patients who were diagnosed with cryptogenic CVA. Mean age at the procedure was 54 ± 19 years. The presence of spontaneous interatrial right-to-left shunts was demonstrated by transesophageal contrast echocardiography without Valsalva maneuver in all of the patients. Amplatzer Cribriform device (n = 4) or Amplatzer PFO Occluder (n = 3) was used for the procedure and was successfully deployed. Device-related complications were not observed at the time of the procedure or during the follow-up period (mean period of 16 ± 9 months). Catheter closure of a PFO could be safely performed with Amplatzer Cribriform or Amplatzer PFO Occluder. This procedure may contribute to prevention of recurrent cryptogenic CVA in Japanese patients.

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Acknowledgments

The authors thank Yasuharu Tanabe, Nobuhisa Watanabe, Rika Takemoto and Madoka Ikeda for supporting this study and correcting the clinical data. This study was not supported by any funding. The authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Yasufumi Kijima, Koji Nakagawa, Akira Ueoka, Norihisa Toh, Hiroki Oe, Kengo Kusano & Hiroshi Ito

  2. Division of Cardiac Intensive Care Unit, Okayama University Hospital, 2-5-1 Shicata-cho, Kitaku, Okayama, 7008558, Japan

    Teiji Akagi & Shunji Sano

  3. Department of Cardiovascular Medicine, Fukuyama Cardiovascular Hospital, Fukuyama, Japan

    Manabu Taniguchi

  4. Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Kentaro Deguchi

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  1. Yasufumi Kijima
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  2. Teiji Akagi
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  3. Koji Nakagawa
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  4. Manabu Taniguchi
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  7. Norihisa Toh
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  11. Hiroshi Ito
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Correspondence to Teiji Akagi.

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Kijima, Y., Akagi, T., Nakagawa, K. et al. Catheter closure of patent foramen ovale in patients with cryptogenic cerebrovascular accidents: initial experiences in Japan. Cardiovasc Interv and Ther 29, 11–17 (2014). https://doi.org/10.1007/s12928-013-0193-9

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  • DOI: https://doi.org/10.1007/s12928-013-0193-9

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