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Genetic Determinants of Autoimmune Gastritis

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Abstract

Autoimmune gastritis (AIG) is an immuno-mediated disease characterized by the production of antibodies to the parietal cells of the stomach, which leads to the loss of the internal Castle factor and decrease in the production of hydrochloric acid. Diagnosis of AIG remains difficult due to the lack of symptoms at early stages, ineffective or costly screening strategies, and incomplete established etiology. Patients with AIG are at high risk of developing malignant neoplasms and neuroendocrine tumors, and they would greatly benefit from any means to predict the likelihood of developing and the severity of a possible disease. Here, we aim to summarize data on the genetic nature of AIG. We will also describe the clinical picture of AIG, Helicobacter pylori association with it, and elaborate on the pathogenesis of the disease.

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Acknowledgements

This paper was supported by the Kazan Federal University Strategic Academic Leadership Program (PRIORITY-2030).

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Authors and Affiliations

  1. Center for Personalized Medicine, GBUZ Moscow Clinical Scientific and Practical Center Named After A.S. Loginov DZM, Moscow, Russia

    Vera Polyakova, Airat Bilyalov & Tatiana Yanova

  2. Center for Personalized Medicine, State Budgetary Healthcare Institution of Moscow «Moscow Clinical Scientific Practical Center Named After A.S. Loginov» of the Health Department of Moscow, Moscow, Russia

    Natalia Bodunova, Konstantin Rumyantsev, Igor Khatkov & Philipp Sviridov

  3. Medical Sciences, Russian Academy of Sciences, Moscow, Russia

    Igor Khatkov

  4. Department of Pancreatic, Biliary and Upper Digestive Tract Disorders, Department of Outpatient Therapy and Family Medicine, A.S. Loginov Moscow Clinical Scientific Center, Moscow, Russia

    Dmitry Bordin

  5. Tver State Medical University, Tver, Russia

    Dmitry Bordin

  6. Department of Propaedeutic of Internal Diseases and Gastroenterology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia

    Dmitry Bordin

  7. Kazan Federal University, Kazan, Russia

    Airat Bilyalov

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  1. Vera Polyakova
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Contributions

Concept and design of the study: Vera Polyakova, Natalia Bodunova, Igor Khatkov, Dmitry Bordin, Tatiana Yanova.

Collection and processing of materials: Vera Polyakova, Tatiana Yanova.

Statistical processing: Airat Bilyalov, Philipp Sviridov, Konstantin Rumyantsev.

Text writing: Vera Polyakova, Natalia Bodunova, Konstantin Rumyantsev, Dmitry Bordin, Philipp Sviridov, Tatiana Yanova.

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Correspondence to Vera Polyakova.

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Polyakova, V., Bodunova, N., Rumyantsev, K. et al. Genetic Determinants of Autoimmune Gastritis. BioNanoSci. 13, 322–329 (2023). https://doi.org/10.1007/s12668-023-01068-3

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