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Fabrication, Characterization and In Vitro Antifungal Property Evaluation of Biocompatible Lignin-Stabilized Zinc Oxide Nanoparticles Against Selected Pathogenic Fungal Strains

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Abstract

The present work aims to develop photoresponsive nanoparticle incorporated biomacromolecular aggregates with excellent optical and antimicrobial properties by the apt combination of zinc oxide nanoparticles with lignin, a macromolecular binding system. The biopolymer lignin-stabilized zinc oxide nanoparticles were fabricated by a cost-effective chemical precipitation route. The synthesized ZONPs and lignin-stabilized ZONPs were characterized by UV-visible, FT-IR and fluorescence spectrophotometric techniques, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD) analyses. The antifungal efficacy evaluation of the developed ZONP encapsulated lignin aggregates was done against selected pathogenic fungal strains. The study established the use of ZONPs encapsulated in water-soluble and biocompatible macro matrix lignin as an effective antifungal agent in order to improve the antimicrobial performance in biomedical and environmental applications.

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Funding

This work was supported by the University Grants Commission SWRO, Bangalore under the FDP scheme (No. FIP/12th Plan/KLMG028 TF- 04; 12.04.2017).

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Authors and Affiliations

  1. Research and Post Graduate Department of Chemistry, St. Thomas College, Palai, Kerala, 686574, India

    Linta Maria Jose & Sunny Kuriakose

  2. Research and Post Graduate Department of Chemistry, Kuriakose Elias College, Mannanam, Kerala, 686561, India

    Linta Maria Jose

  3. School of Chemical Sciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, 686560, India

    Sabu Thomas

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  1. Linta Maria Jose
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Correspondence to Sunny Kuriakose.

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Jose, L.M., Kuriakose, S. & Thomas, S. Fabrication, Characterization and In Vitro Antifungal Property Evaluation of Biocompatible Lignin-Stabilized Zinc Oxide Nanoparticles Against Selected Pathogenic Fungal Strains. BioNanoSci. 10, 583–596 (2020). https://doi.org/10.1007/s12668-020-00748-8

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