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Evaluation of Nickel Neurotoxicity and High Sorption through a Hybrid Yeast / Silsesquioxane Material

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Abstract

The presence of heavy metals in water is one of the major concerns in the public health area. So, the characterization of inorganic compounds toxicity and their detection, speciation and removal are some of the biggest environmental challenges today. Within this context, the present work evaluated the effect caused by Ni2+ in neuronal autofluorescence recorded in brain slices. Besides, a bioinorganic nanostructured hybrid material with great potential for heavy metals removal: yeast Saccharomyces cerevisiae modified with Silsesquioxane was applied for Ni2 sorption. The neurotoxicity tests revealed that in the presence of Ni2+ concentrations of 10, 20 and 30 μM (0.5, 1.0 and 1.5 ppm), irreversible autofluorescence changes occurred. In the sorption tests, the hybrid material revealed a maximum capacity of sorption of 64.6 mg/g. This material was able to reach 77.7% of removal of the initial Ni2+ solution using a 100 cm3/g liquid/solid ratio, at pH 6 and 15 min of contact time.

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Acknowledgements

The author Bianca Trama Freitas acknowledges the CNPq (Process 205379/2014-1) for the financial support. Rui C. Martins acknowledges the IFCT 2014 programme (IF/00215/2014) with financing from the European Social Fund and the Human Potential Operational Programme. The Biophysics Group thanks the CNC– Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, for providing the rat brains. Their work was funded by strategic project UID/NEU/04539/2013.

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Authors and Affiliations

  1. Departamento de Física e Química, Faculdade de Engenharia de Ilha Solteira, Univ. Estadual Paulista-UNESP, Av. Brasil Centro, 56 CEP 15385-000, Ilha Solteira, São Paulo, Brazil

    Bianca Trama-Freitas, Fernanda Franco & Devaney R. do Carmo

  2. Department of Chemical Engineering, CIEPQPF- Research Center of Chemical Process Engineering and Forest Products, University of Coimbra, P-3030-790, Coimbra, Portugal

    Rui C. Martins, Licínio M. Gando-Ferreira & Rosa Maria Quinta-Ferreira

  3. Department of Physics and CNC- Center for Neuroscience and Cell Biology, University of Coimbra, P-3004-516, Coimbra, Portugal

    Maria Emília Quinta-Ferreira

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  1. Bianca Trama-Freitas
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  2. Fernanda Franco
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  3. Rui C. Martins
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  4. Licínio M. Gando-Ferreira
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  5. Maria Emília Quinta-Ferreira
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  6. Rosa Maria Quinta-Ferreira
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  7. Devaney R. do Carmo
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Correspondence to Devaney R. do Carmo.

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Trama-Freitas, B., Franco, F., Martins, R.C. et al. Evaluation of Nickel Neurotoxicity and High Sorption through a Hybrid Yeast / Silsesquioxane Material. Silicon 13, 259–265 (2021). https://doi.org/10.1007/s12633-020-00420-6

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  • DOI: https://doi.org/10.1007/s12633-020-00420-6

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