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Synthesis and Characterization of Hollow Mesoporous Silica Spheres and Studying the Load and Release of Dexamethasone

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Abstract

Hollow mesoporous silica (HMS) spheres were synthesized using cetyltrimethylammonium bromide (CTAB) and carbon nanospheres as a hard template through a hydrothermal procedure. The prepared HMS was characterized by UV-Vis, FT-IR, TG, XRD, BET and SEM measurements. HMS was functionalized using aminopropyltriethoxysilane (APTES) and amino groups were linked on its surface. Synthesized mesoporous material consists of homogenous particles with a size about 500-600 nm. Channels on the shell have hexagonal arrangements. In comparison with MCM41 and SBA15, spherical HMS provides more volume for drug loading, for its hollow cores. Thereby, the ability of obtained mesoporous materials to load and release of dexamethasone as a drug was studied.

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References

  1. Chen X, Kierzek K, Jiang Z, Chen H, Tang T, Wojtoniszak M, Kalenczuk RJ, Chu PK, Borowiak-Palen E (2011) Synthesis, growth mechanism, and electrochemical properties of hollow mesoporous carbon spheres with controlled diameter. J Phys Chem C 115:17717

    Article  CAS  Google Scholar 

  2. Chen Y, Chen H, Shi J (2014) Construction of homogenous/heterogeneous hollow mesoporous silica nanostructures by silica-etching chemistry: principles, synthesis, and applications. J Acc Chem Res 47(1):125

    Article  CAS  Google Scholar 

  3. Qiao SZ, Lin CX, Jin Y, Li Z, Yan Z, Hao Z, Huang Y (2009) Lu GQ(M). Surface-functionalized periodic mesoporous organosilica hollow spheres. J Phys Chem C 113(20):8673

    CAS  Google Scholar 

  4. Teng Z, Su X, Zheng Y, Sun J, Chen G, Tian C, Wang J, Li H, Zhao Y, Lu G (2013) Mesoporous silica hollow spheres with ordered radial mesochannels by a spontaneous self-transformation approach. Chem Mater 25(1):98

    Article  CAS  Google Scholar 

  5. Parambadath S, Rana V K, Moorthy S, Chu S, Park S, Lee D, Sung G, Ha C (2011) Periodic mesoporous organosilicas with co-existence of diurea and sulfanilamide as an effective drug delivery carrier. J Solid State Chem 184(5):1208

    Article  CAS  Google Scholar 

  6. Zhu Y, Jian D, Wang S (2011) Investigation of loading and release of guest molecules from hollow mesoporous silica spheres. Micro Nano Lett 6(9):802

    Article  CAS  Google Scholar 

  7. Lin CX(C), Qiao SZ, Yu CZ, Ismadji S, Lu GQ(M) (2009) Periodic mesoporous silica and organosilica with controlled morphologies as carriers for drug release. J Micropor Mesopor Mat 117:213

    Article  Google Scholar 

  8. Zhang L, Feng X, Liu H, Qian D, Zhang L, Yu X, Cui F (2004) Hydroxyapatite/collagen composite materials formation in simulated body fluid environment. J Mater Lett 58(5):719

    Article  CAS  Google Scholar 

  9. Sasidharan M, Bhaumik A (2013) Novel and mild synthetic strategy for the sulfonic acid functionalization in periodic mesoporous ethenylene-silica. J Appl Mater Interfaces 5:2618

    Article  CAS  Google Scholar 

  10. Moorthy MS, Park S, Fuping D, Hong S, Selvaraj M, Ha C (2012) Step-up synthesis of amidoxime-functionalised periodic mesoporous organosilicas with an amphoteric ligand in the framework for drug delivery. J Mater Chem 22:9100

    Article  Google Scholar 

  11. Luo Y, Yang P, Lin J (2008) Synthesis and characterization of urea bridged hybrid periodic mesoporous organosilica materials. Micropor Mesopor Mat 111:194

    Article  CAS  Google Scholar 

  12. Sevilla M, Fuertes AB (2009) The production of carbon materials by hydrothermal carbonization of cellulose. J Carbon 47 (9): 2281

    Article  CAS  Google Scholar 

  13. Luigi R, Francesco C, Raffaele C, Ilaria R (2011) A mechanochemical approach to porous silicon nanoparticles fabrication. J Mater 4(6):1023

    Article  Google Scholar 

  14. Nakamoto K (2009) Infrared and raman spectra of inorganic and coordination compounds Part B, 6th edn. Wiley, New Jersey

    Google Scholar 

  15. Sadtler SP (1978) Handbook of infrared spectra. Bio-Red Laboratories

  16. Tadjarodi A, Haghverdi M, Mohammadi V (2012) Preparation and characterization of nano-porous silica aerogel from rice husk ash by drying at atmospheric pressure. J Mater Res Bull 47:2584

    Article  CAS  Google Scholar 

  17. Moritz M, Geszke-Moritz M (2015) Mesoporous silica materials with different structures as the carriers for antimicrobial agent. Modeling of chlorhexidine adsorption and release. J Appl Surf Sci 356:1327

    Article  CAS  Google Scholar 

  18. Saikia L, Srinivas D, Ratnasamy P (2006) Chemo, regio- and stereo-selective aerial oxidation of limonene to the endo-1,2-epoxide over Mn(Salen)-sulfonated SBA15. J Appl Catal A-Gen 309:144

    Article  CAS  Google Scholar 

  19. Bagherzadeh M, Zare M, Amini M, Salemnoush T, Akbayrak S, Özkar S (2014) Epoxidation of olefins catalyzed by a molybdenum-Schiff base complex anchored in the pores of SBA-15. J Mol Catal A-Chem 395:470

    Article  CAS  Google Scholar 

  20. Perez-Quintanilla D, Sanchez A, Del Hierro I, Fajardo M, Sierra I (2009) Preconcentration of Zn(II) in water samples using a new hybrid SBA-15-based material. J Hazard Mater 166:1449

    Article  CAS  Google Scholar 

  21. Jaeger DA, Reddy VB, Bohle DS (1999) Cleavable double-chain surfactant Co(III) complexes. Tetrahedron Lett 40(4):649

    Article  CAS  Google Scholar 

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Acknowledgements

The authors are grateful to the financial support of Iran University of Science and Technology.

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Authors and Affiliations

  1. Department of Chemistry, Iran University of Science and Technology, Tehran, 1684613114, Iran

    M. Amin Al Roaya, F. Manteghi & M. Haghverdi

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  1. M. Amin Al Roaya
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  2. F. Manteghi
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  3. M. Haghverdi
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Corresponding author

Correspondence to F. Manteghi.

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Al Roaya, M.A., Manteghi, F. & Haghverdi, M. Synthesis and Characterization of Hollow Mesoporous Silica Spheres and Studying the Load and Release of Dexamethasone. Silicon 11, 1401–1411 (2019). https://doi.org/10.1007/s12633-018-9943-8

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