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Changes in the Human Gut Microbiome Caused by the Short-Term Impact of Lactic Acid Bacteria Consumption in Healthy People

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Abstract

The gut microbiome is one of the main factors affecting human health. It has been proven that probiotics can regulate the metabolism in the host body. A large number of people use probiotics not as medicines, but as a prophylactic supplement. The aim of our study was to evaluate the effect of lactic acid bacteria on the gut microbiome of healthy people using the V3 region of the 16S rRNA gene. Our study showed changes in the generic composition in the gut of healthy people when taking the supplement. There was an increase in the members responsible for the production of short-chain fatty acids in the gut of the host (Blautia, Fusicatenibacter, Eubacterium hallii group, Ruminococcus), as well as bacteria that improve intestinal homeostasis (Dorea and Barnesiella). There was also a decrease in the abundance of bacteria in the genera Catenibacterium, Hungatella, Escherichia-Shigella, and Pseudomonas, associated with an unhealthy profile of the human gut microbiome. An increase in members of the phylum Actinobacteriota was also observed, which has a positive effect on the host organism. Our results indicate that short-term prophylactic use of lactic acid bacteria-based supplements can be effective, as it contributes to a beneficial effect on the gut microbiome of healthy people.

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Data Availability

Sequencing data is available in NCBI BioProject database (BioProject:PRJNA 860108).

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Funding

This work was supported by Ministry of Science and Higher Education of the Russian Federation in the framework of the national project “Science” (project FZGW-2020–0001, unique number of the register of State tasks 075001X39782002).

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Authors and Affiliations

  1. Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036, Voronezh, Russia

    Mariya Gryaznova, Yuliya Smirnova, Inna Burakova, Mikhail Syromyatnikov, Evgeny Popov & Vasily Popov

  2. Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018, Voronezh, Russia

    Mariya Gryaznova, Yuliya Smirnova, Mikhail Syromyatnikov, Pavel Chizhkov & Vasily Popov

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  1. Mariya Gryaznova
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Contributions

Conceptualization: M.S., E.P., and V.P.; methodology: M.S. and E.P.; software: M.G.; validation: M.G. and Yu.S.; formal analysis: M.G., I.B., and Yu.S.; investigation: I.B. and Yu.S.; resources: M.S., P.Ch., and V.P.; data curation: M.G. and Yu.S.; writing—original draft preparation: M.G., Yu.S., I.B., and P.Ch.; writing—review and editing: M.S. and V.P.; visualization: M.G. and I.B.; supervision: M.S. and V.P.; project administration: V.P.; funding acquisition: V.P. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Mikhail Syromyatnikov.

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Gryaznova, M., Smirnova, Y., Burakova, I. et al. Changes in the Human Gut Microbiome Caused by the Short-Term Impact of Lactic Acid Bacteria Consumption in Healthy People. Probiotics & Antimicro. Prot. (2023). https://doi.org/10.1007/s12602-023-10111-4

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