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P450-mediated detoxification of botanicals in insects

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Abstract

In recent years, botanical insecticides have gradually replaced the traditional synthetic insecticides, with the properties of strong pertinence and environment friendly. Many new botanical insecticides are developed and used, meanwhile insect develop its resistance to these insecticides. Previous studies have proved that Cytochrome P450 monooxygenases (CYPs) play a critical role in insect detoxification. Genomic and proteomic approaches focused on P450 expression and regulation at the transcript and protein levels have made substantial progress. The review covers the recent years’ research of typical botanicals metabolism mediated by CYPs, the relationship between function and structural characters of P450 enzymes, as well as the expression and regulation of related P450 genes in botanicals metabolism.

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Abbreviations

CYPs:

Cytochrome P450 monooxygenases

MRPs:

Multidrug resistance-associated protein transporters

SRS:

Substrate recognition site

TEs:

Transposable elements

XRE-xan:

Xenobiotic response element

XRE-AhR:

Putative elements

nAChRs:

Nicotinic acetylcholine receptors

SNO:

Senecionine N-oxygenase

PAs:

Pyrrolizidine alkaloids

JH:

Insect juvenile hormone

LTR:

Long terminal repeat

OCT-1:

Octamer-1 binding site element

EcRE:

Ecdysone-responsive element

EBP:

Enhancer-binding protein C

CPR:

Cytochrome P450 reductase

dsRNA:

Double-stranded RNA

RNAi:

RNA interference

PIs:

Proteinase inhibitors

FMN:

Flavin mononucleotide

Inr:

Consensus arthropod initiator element

STRE:

Stress response elements

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Acknowledgments

The authors would like to thank the reviewers for their critical comments. The work supported by grants from SJTU 985-III disciplines platform and talent funds (grant no. TS0320215002), the National Natural Science Foundation of China (grant no. 31401703) and SJTU startup foundation for new young faculty (grant no. 14X100040073).

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  1. School of Agriculture and Biology, Shanghai Jiao Tong University, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, 800 Dongchuan Road, Shanghai, 200240, China

    Sufen Cui, Lei Wang, Long Ma & Xueqing Geng

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  1. Sufen Cui
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  2. Lei Wang
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  3. Long Ma
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  4. Xueqing Geng
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Correspondence to Xueqing Geng.

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Cui, S., Wang, L., Ma, L. et al. P450-mediated detoxification of botanicals in insects. Phytoparasitica 44, 585–599 (2016). https://doi.org/10.1007/s12600-016-0550-1

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