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Recent advances on bioreceptors and metal nanomaterials-based electrochemical impedance spectroscopy biosensors

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Abstract

Metal-based nanomaterials have a wide range of applications in energy conversion, catalysis, bioimaging, and sensors. In our review, we mainly introduce metal nanomaterials-based electrochemical impedance spectroscopy (EIS) biosensors in medical healthcare, environmental monitoring, and food safety instructively, with collecting and analyzing the current achievement of predecessors. In general, metal nanomaterials-based EIS biosensors can be divided into four components, in which bioreceptors and metal nanomaterials transducers are vital for designs. Bioreceptors and metal nanomaterials determine the feasibility, specificity, sensitivity and simplicity of manufacturing and operations. With the demonstration and discussion of bioreceptors and metal nanomaterials of biosensors in different fields, our review aims to assist brief acknowledgement of current state-of-the-art achievement and provide our insights for the future development.

Graphical abstract

摘要

金属基纳米材料在能量转换、催化、生物成像和传感器等领域有着广泛的应用。 在我们的综述中，我们主要介绍 了基于金属纳米材料的电化学阻抗谱（EIS）生物传感器在医疗保健、环境监测和食品安全方面的应用，并收集 和分析了前人目前的成果。 一般来说，基于金属纳米材料的 EIS 生物传感器可分为四个部分，其中生物受体和 金属纳米材料换能器对设计至关重要。 生物受体和金属纳米材料决定了制造和操作的可行性、特异性、敏感性和 简单性。 通过对生物受体和生物传感器金属纳米材料在不同领域的演示和讨论，我们的综述旨在帮助简要了解 当前的成就并激发未来的巨大创新。

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Fig. 1
Fig. 2

Reproduced with permission from Ref. [23]. Copyright 2015, Royal Society of Chemistry. b Hair-pin structure change of aptamers, where IFN-γ is interferon. Reproduced with permission from Ref. [28]. Copyright 2010, American Chemical Society. c Structure change of MBs, where dNTP is deoxynucleotides and ICSDPR is isothermal circular strand displacement polymerization reaction. Reproduced with permission from Ref. [33]. Copyright 2021, Elsevier B.V

Fig. 3

Reproduced with permission from Ref. [41]. Copyright 2019, MDPI. b Demonstration of receptor-based biosensors, where pTBS is electrically-conducting poly[toluidine blue]. Reproduced with permission from Ref. [45]. Copyright 2020, Elsevier B.V. c Example of receptor-based biosensors. Reproduced with permission from Ref. [51]. Copyright 2018, Elsevier B.V. d Structures of a peptide-based biosensor, where SAM is self-assembly monolayer. Reproduced with permission from Ref. [58]. Copyright 2018, Elsevier B.V

Fig. 4

Reproduced with permission from Ref. [63]. Copyright 2016, Portland Press LTD. b Different types and their structures of glycolipids. Reproduced with permission from Ref. [64]. Copyright 2017, Springer Science Business Media, LLC. c Lectin–carbohydrate interactions. Reproduced with permission from Ref. [65]. Copyright 2019, Elsevier Inc. d Liposomes and lipid bilayers in biosensors. Reproduced with permission from Ref. [70]. Copyright 2017, Elsevier B.V

Fig. 5

Reproduced with permission from Ref. [74]. Copyright, 2019 Elsevier B.V

Fig. 6

Reproduced with permission from Ref. [95]. Copyright 2019, MDPI

Fig. 7

Reproduced with permission from Ref. [114]. Copyright 2018, Springer-Verlag GmbH Austria, part of Springer Nature

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Acknowledgements

This work was financially sponsored by the National Natural Science Foundation of China (Nos. 51672204 and 22102128) and ZY thanks UK NERC Fellowship Grant (No. NE/R013349/2).

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  1. School of Materials and Science Engineering, Wuhan University of Technology, Wuhan, 430070, China

    Zi-Bo Chen & Da-Ping He

  2. Hubei Engineering Research Center of RF-Microwave Technology and Application, School of Science, Wuhan University of Technology, Wuhan, 430070, China

    Hui-Hui Jin & Da-Ping He

  3. School of Water, Energy and Environment, Cranfield University, Cranfield, MK43 0AL, UK

    Zhu-Gen Yang

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Chen, ZB., Jin, HH., Yang, ZG. et al. Recent advances on bioreceptors and metal nanomaterials-based electrochemical impedance spectroscopy biosensors. Rare Met. 42, 1098–1117 (2023). https://doi.org/10.1007/s12598-022-02129-4

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