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Highly sensitive PCF-SPR biosensor for hyperthermia temperature monitoring

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Abstract

A highly sensitive photonic crystal fiber based on a surface plasmon resonance (PCF-SPR) biosensor is designed for local temperature detection in brain tumor treatment. In order to obtain high sensitivity, the mixture of chloroform and toluene whose refractive index is temperature sensitive and is injected into the analyte channel coated with a thin gold layer. The temperature sensing performance and coupling properties of the PCF-SPR biosensor are numerically simulated by the finite-element method. By means of the wavelength interrogation method, a maximum temperature sensitivity of − 6000 pm/°C is achieved for the temperature sensing range between − 50 °C and 100 °C, corresponding to a resolution of the PCF-SPR temperature biosensor as low as 0.017 °C. The temperature sensitivity is the largest among the reported PCF-SPR sensors, to the best of our knowledge. Owing to the high sensitivity and resolution, the proposed biosensor has the potential to be used for hyperthermia monitoring in brain tumor treatment.

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Acknowledgements

This work jointly was jointly supported by the National Natural Science Foundation of China (Grant Number 51474069), China Postdoctoral Science Foundation funded project (Grant Number 2016M591510), Natural Science Foundation of Heilongjiang Province (Grant Number E2017010), as well as City University of Hong Kong Applied Research Grant (ARG) (Number 9667122).

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Authors and Affiliations

  1. Institute of Materials Processing and Intelligent Manufacturing and Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin, 150001, People’s Republic of China

    Famei Wang & Zhijie Sun

  2. Institute of Microelectronics, Agency of Science, Technology and Research (A*STAR), Singapore, 117685, Singapore

    Tao Sun

  3. School of Electronics Science, Northeast Petroleum University, Daqing, 163318, People’s Republic of China

    Chao Liu

  4. Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, People’s Republic of China

    Paul K. Chu

  5. Department of Foreign Languages, Harbin Engineering University, Harbin, 150001, People’s Republic of China

    Liying Bao

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  1. Famei Wang
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  2. Zhijie Sun
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  3. Tao Sun
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  4. Chao Liu
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Correspondence to Famei Wang or Zhijie Sun.

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Wang, F., Sun, Z., Sun, T. et al. Highly sensitive PCF-SPR biosensor for hyperthermia temperature monitoring. J Opt 47, 288–294 (2018). https://doi.org/10.1007/s12596-018-0468-8

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  • DOI: https://doi.org/10.1007/s12596-018-0468-8

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