Abstract
Chaetomium globosum is one of the most common species of fungi found growing on damp building materials in North America and Europe. At doses that could be experienced in a building with some mould damage, exposure to metabolites from other fungi results in inflammatory changes in vivo and in vitro. This research requires knowledge of the dominant toxins produced by fungal strains from the built environment and characterization of pure compounds for toxicity testing. We examined 25 strains of C. globosum isolated from the built environment in Canada. In varying amounts, these strains primarily produced chaetoglobosin A, C and F, chaetomugilin D, and chaetoviridin A. Spectroscopic data of the major isolated compounds are provided. Previous studies reported a number of metabolites from this species that we did not find. However, this appears to be due to misidentifications of the fungi they examined as well as problems with the analytical methods used. In addition, our data support the use of metabolite profiles for resolving the taxonomy of some economically important Chaetomium species.
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Acknowledgments
This research was funded by a NSERC IRC to JDM and an OGS to DRM. We thank Don Belisle and Dr. Tom Rand for collection of samples as well as Dan Sørensen for LC-MS analysis.
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McMullin, D.R., Sumarah, M.W. & Miller, J.D. Chaetoglobosins and azaphilones produced by Canadian strains of Chaetomium globosum isolated from the indoor environment. Mycotoxin Res 29, 47–54 (2013). https://doi.org/10.1007/s12550-012-0144-9
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DOI: https://doi.org/10.1007/s12550-012-0144-9