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PS11 - 1. Longitudinal eGFR trajectories in patients with type 2 diabetes

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Nederlands Tijdschrift voor Diabetologie Aims and scope

Abstract

The decline in glomerular filtration rate (GFR) is used as outcome parameter to establish drug efficacy in clinical trials of renal disease progression. For analyzing and interpretation of trial results it is assumed that renal function declines linearly over time. However, a recent study in Afro- Americans with hypertensive nephrosclerosis documented that 42% of patients exhibit > 90% probability of non-linear GFR trajectory or prolonged period of nonprogression.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, UMCG, Groningen, The Netherlands

    Misghina Weldegiorgis, Dick de Zeeuw, Paul Smink & Hiddo Lambers Heerspink

  2. University of Utah, Salt Lake City UT, USA

    Tom Greene

  3. Cleveland Clinic, Cleveland, OH, USA

    Liang Li

  4. Steno Diabetes Center, Gentofte, Denmark

    Peter Rossing

Authors
  1. Misghina Weldegiorgis
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  2. Dick de Zeeuw
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  3. Tom Greene
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  4. Liang Li
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  5. Peter Rossing
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  6. Paul Smink
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  7. Hiddo Lambers Heerspink
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Corresponding author

Correspondence to Misghina Weldegiorgis.

Additional information

Parallel session 11. 14:00-15:00 diabetes, microvascular complications and cancer (nsdeg)

1 Department of Clinical Pharmacology, UMCG, Groningen, Groningen, The Netherlands, 2University of Utah, Salt Lake City UT, USA, 2 Cleveland Clinic, Cleveland, OH, USA, 3 Steno Diabetes Center, Gentofte, Denmark. E-mail: m.weldegiorgis@umcg.nl

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Weldegiorgis, M., de Zeeuw, D., Greene, T. et al. PS11 - 1. Longitudinal eGFR trajectories in patients with type 2 diabetes. NED. TIJDSCHR. DIABET. 11, 162 (2013). https://doi.org/10.1007/s12467-013-0107-6

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  • DOI: https://doi.org/10.1007/s12467-013-0107-6

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