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A case of successful treatment with lenvatinib in primary hepatoid adenocarcinoma of the gallbladder that was difficult to distinguish from hepatocellular carcinoma

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Abstract

Hepatoid adenocarcinoma (HAC) is an adenocarcinoma with components similar to those of hepatocellular carcinoma. Primary HAC of the gallbladder is extremely rare; to our knowledge, there is no consensus on the treatment after diagnosis. We reported an 82-year-old Japanese female of primary HAC of the gallbladder with postoperative recurrence that responded to lenvatinib. A total of 9 months has passed since the start of chemotherapy with lenvatinib, and the patient is in good general condition. To establish an effective treatment for primary HAC of the gallbladder, further accumulation and investigation of cases are recommended.

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Acknowledgements

We thank Robert E. Brandt, Founder, CEO, and CME, of MedEd Japan, for editing and formatting the manuscript.

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The authors have received no funding for the publication of this article.

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Authors and Affiliations

  1. Department of Gastroenterology, Internal Medicine, Kitasato University Hospital, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan

    Shuichiro Iwasaki, Hisashi Hidaka, Haruki Uojima, Naohisa Wada, Kousuke Kubota, Takahide Nakazawa, Akitaka Shibuya & Chika Kusano

  2. Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan

    Hidefumi Kubo

  3. Department of Surgery, Kitasato University School of Medicine, Sagamihara, Japan

    Kai Adachi

Authors
  1. Shuichiro Iwasaki
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  2. Hisashi Hidaka
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  3. Haruki Uojima
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  4. Hidefumi Kubo
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  5. Kai Adachi
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  6. Naohisa Wada
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  7. Kousuke Kubota
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  8. Takahide Nakazawa
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  9. Akitaka Shibuya
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  10. Chika Kusano
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by HU, HK, KA, NW, KK, TN, AS, and CK. The first draft of the manuscript was written by SI and HH, and all authors critically reviewed the manuscript. All authors approved the final manuscript.

Corresponding author

Correspondence to Hisashi Hidaka.

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This case report follows the precepts of the Declaration of Helsinki.

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Iwasaki, S., Hidaka, H., Uojima, H. et al. A case of successful treatment with lenvatinib in primary hepatoid adenocarcinoma of the gallbladder that was difficult to distinguish from hepatocellular carcinoma. Clin J Gastroenterol 15, 1108–1114 (2022). https://doi.org/10.1007/s12328-022-01686-6

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  • DOI: https://doi.org/10.1007/s12328-022-01686-6

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