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Imatinib and nutritional support can make successful treatment for a case of huge liver metastasis of duodenal gastrointestinal stromal tumor that initially showed jaundice and cachexia

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Abstract

It is very difficult to treat patients with liver metastasis presenting with jaundice or cachexia. We herein report a successfully treated case of huge liver metastasis of gastrointestinal stromal tumor (GIST) that initially showed jaundice and cachexia. The patient was a woman in her early 40 s. She had a history of duodenal GIST 4 years before this admission. She was admitted to our hospital for abdominal fullness and anorexia. Abdominal computed tomography revealed huge liver metastasis of GIST. She showed jaundice and cancer cachexia with a modified Glasgow Prognostic Score of 2. After applying nutritional support, 400 mg of imatinib was administered. Although leg edema transiently worsened, the withdrawal of imatinib and administration of diuretics improved it. Imatinib was re-administered, and nutritional support was continued. The total bilirubin level decreased, and the serum albumin level increased. The tumor gradually decreased in size. Finally, she received surgical resection after 16 months of treatment with imatinib. Although adjuvant imatinib administration was continued after surgery, and no recurrence was observed as of 18 months after surgery.

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Authors and Affiliations

  1. Department of Gastroenterology, National Hospital Organization Takasaki General Medical Center, 36 Takamatsu-cho, Takasaki, Gunma, 370-0829, Japan

    Yumeo Tateyama, Atsushi Naganuma, Yuhei Suzuki, Tomoyuki Masuda, Sanae Uehara, Takashi Hoshino, Hidetoshi Yasuoka, Tomohiro Kudo & Satoru Kakizaki

  2. Nutrition Support Team, National Hospital Organization Takasaki General Medical Center, 36 Takamatsu-cho, Takasaki, Gunma, 370-0829, Japan

    Yusuke Ogawa

  3. Department of Surgery, National Hospital Organization Takasaki General Medical Center, 36 Takamatsu-cho, Takasaki, Gunma, 370-0829, Japan

    Tetsushi Ogawa

  4. Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan

    Kohei Tateno, Norihiro Ishii, Kenichiro Araki, Norifumi Harimoto & Ken Shirabe

  5. Department of Clinical Research, National Hospital Organization Takasaki General Medical Center, 36 Takamatsu-cho, Takasaki, Gunma, 370-0829, Japan

    Satoru Kakizaki

Authors
  1. Yumeo Tateyama
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  2. Atsushi Naganuma
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  3. Yuhei Suzuki
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  9. Yusuke Ogawa
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  11. Kohei Tateno
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  12. Norihiro Ishii
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  14. Norifumi Harimoto
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  16. Satoru Kakizaki
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Correspondence to Satoru Kakizaki.

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All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Tateyama, Y., Naganuma, A., Suzuki, Y. et al. Imatinib and nutritional support can make successful treatment for a case of huge liver metastasis of duodenal gastrointestinal stromal tumor that initially showed jaundice and cachexia. Clin J Gastroenterol 14, 570–576 (2021). https://doi.org/10.1007/s12328-021-01340-7

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  • DOI: https://doi.org/10.1007/s12328-021-01340-7

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