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The Role of Interleukins in the Pathogenesis of Dermatological Immune-Mediated Diseases

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Abstract

Autoimmune inflammatory diseases are primarily characterized by deregulated expression of cytokines, which drive pathogenesis of these diseases. A number of approved and experimental therapies utilize monoclonal antibodies against cytokine proteins. Cytokines can be classified into different families including the interleukins, which are secreted and act on leukocytes, the tumor necrosis factor (TNF) family, as well as chemokine proteins. In this review article, we focus on the interleukin family of cytokines, of which 39 members have been identified to this date. We outline the role of each of these interleukins in the immune system, and various dermatological inflammatory diseases with a focused discussion on the pathogenesis of psoriasis and atopic dermatitis. In addition, we describe the roles of various interleukins in psychiatric, cardiovascular, and gastrointestinal comorbidities. Finally, we review clinical efficacy and safety data from emerging late-phase anti-interleukin therapies under development for psoriasis and atopic dermatitis. Collectively, additional fundamental and clinical research remains necessary to fully elucidate the roles of various interleukin proteins in the pathogenesis of inflammatory dermatologic diseases, and treatment outcomes in patients.

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Acknowledgements

Funding

Publication fees were covered by Bausch Health Canada Inc.

Medical Writing and Editorial Assistance

The authors wish to acknowledge Houssam Ismail, PhD, for providing medical writing assistance with this manuscript, which was funded by Bausch Health Canada, Inc. Dr. Ismail is a freelance medical writer employed by STA HealthCare Communications. The authors also would like to thank Dr. Yuka Asai for critical reading of the manuscript.

Author Contributions

I.T. and M.B. conceived and designed the outline of the work, and co-wrote the manuscript.

Disclosures

Dr. Turchin was a consultant, speaker and investigator for AbbVie, Amgen, Arcutis, Aristea, Bausch Health, Boehringer Ingelheim, Celgene, Eli Lilly, Galderma, Incyte, Janssen, Kiniksa, LeoPharma, Novartis, Pfizer, Sanofi, UCB. Dr. Bourcier was a consultant speaker for AbbVie, Amgen-Wyeth, Bausch Health, Celgene, Eli-Lilly, GSK, Janssen, LEO Pharma, Pfizer Novartis, Sanofi, UCB and was an advisor for AbbVie, Amgen-Wyeth, Bausch Health, BMS, Celgene, Eli-Lilly, Janssen, LEO Pharma, Pfizer, Novartis, Sanofi, UCB. He has been a principal investigator for the following companies: AbbVie, Amgen, Celgene, Eli-Lilly, Janssen, Leo, Novartis.

Compliance with Ethics Guidelines

This article is based on previously conducted studies, and does not contain any new studies with human participants or animals performed by any of the authors.

Data Availability

There are no data associated with this review article apart from what is presented and referenced here.

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Authors and Affiliations

  1. Brunswick Dermatology Center, 204 Brunswick Street, Fredericton, NB, E3B 1G9, Canada

    Irina Turchin

  2. Dalhousie University, Halifax, NS, Canada

    Irina Turchin

  3. Probity Medical Research, Waterloo, ON, Canada

    Irina Turchin

  4. Faculty of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada

    Marc Bourcier

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Correspondence to Irina Turchin.

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Turchin, I., Bourcier, M. The Role of Interleukins in the Pathogenesis of Dermatological Immune-Mediated Diseases. Adv Ther 39, 4474–4508 (2022). https://doi.org/10.1007/s12325-022-02241-y

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