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Mutations in the epidermal growth factor receptor gene in non-small cell lung cancer: Impact on treatment beyond gefitinib and erlotinib

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Abstract

Epidermal growth factor receptor (EGFR)-activating mutations in non-small cell lung cancer (NSCLC) are molecular targets for treatment with gefitinib and erlotinib, often resulting in improved response and prolonged progression-free survival. Resistance to these drugs, which develops during treatment, is a problem of paramount importance. Several mechanisms of “acquired resistance” have been discovered and treatments for this specific entity are on the horizon.

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  1. Hospital Grosshansdorf, Woehrendamm 80, D-22927, Grosshansdrof, Hamburg, Germany

    David F. Heigener & Martin Reck

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  1. David F. Heigener
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  2. Martin Reck
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Correspondence to David F. Heigener.

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Heigener, D.F., Reck, M. Mutations in the epidermal growth factor receptor gene in non-small cell lung cancer: Impact on treatment beyond gefitinib and erlotinib. Adv Therapy 28, 126–133 (2011). https://doi.org/10.1007/s12325-010-0096-4

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