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Cinderella in Serum Protein Electrophoresis

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Abstract

Paraproteinemia is characterised by clonal proliferation of plasma cells. A common laboratory finding in paraproteinemia being a monoclonal peak in serum protein electrophoresis (M band). But there are factors which produce a peak similar to M spike in serum protein electrophoresis and these factors are known as pseudoparaproteins. This case report discusses a rare cause of pseudo M spike in a known case of autoimmune hemolytic anaemia due to administration of drug-Rituximab, a monoclonal antibody by itself.

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Abbreviations

AIHA:

Autoimmune hemolytic anemia

CZE:

Capillary zone electrophoresis

Ig:

Immunoglobulin

k:

Kappa

MAT:

Monoclonal antibody therapy

CD:

Cluster of differentiation

LOS:

Length of stay

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Authors and Affiliations

  1. Department of Laboratory Medicine, MIOT Hospitals, No. 4/112, Mount Poonamallee Road, Manapakkam, Chennai, Tamil Nadu, 600089, India

    Srinivas Narasimhachar Chakravarthy, Satish Ramanathan, Smitha Menon, Vijayakumar Valappil, Mathivanan Durairaj & Jayarani Arokia

Authors
  1. Srinivas Narasimhachar Chakravarthy
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  2. Satish Ramanathan
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  3. Smitha Menon
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  4. Vijayakumar Valappil
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  5. Mathivanan Durairaj
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  6. Jayarani Arokia
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Corresponding author

Correspondence to Srinivas Narasimhachar Chakravarthy.

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None of the authors of this study have any conflict of interest.

Ethical Approval

This article contains study with a human participant performed by the authors. Informed consent was obtained from the individual participant included in the study.

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Chakravarthy, S.N., Ramanathan, S., Menon, S. et al. Cinderella in Serum Protein Electrophoresis. Ind J Clin Biochem 33, 113–116 (2018). https://doi.org/10.1007/s12291-017-0643-8

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  • DOI: https://doi.org/10.1007/s12291-017-0643-8

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