Abstract
Thrombocytopenia is a common feature among HIV-positive patients. However, there are few reports about this subject after highly active antiretroviral therapy (HAART) introduction. The authors show a retrospective description of epidemiology, clinical aspects, and treatment observed in 55 HIV-positive outpatients with thrombocytopenia treated in two reference centers for HIV treatment in São Paulo, Brazil. Thirty-four (62%) patients were male, 50 (91%) were Caucasian, with median of lymphocytes TCD4 of 394 cells/mm3. In 63.6% patients, the cause of thrombocytopenia was classified as immune thrombocytopenic purpura and non immune in 25.5%. Regular use of HAART was present in 43.6% of the population studied. In 20% HAART was initiated for thrombocytopenia treatment with improvement in platelets count observed after 3 months. Platelet transfusion was needed in 23.7% of the patients and one patient died due to bleeding. Thrombocytopenia is still common among patients infected with HIV, considered a multifactor disorder, commonly due to immune mechanisms in our cases. In the clinical setting, a diagnostic approach related to the hematological consequences of HIV infection is needed for a better therapy option for this population.
References
Aragão PM, Marques HH (2005) Trombocitopenia associada ao HIV. J Bras Aids 6(4):165–188
Carbonara S, Fiorentino G, Serio G et al (2001) Response of severe HIV associated thrombocytopenia to highly active antiretroviral therapy including protease inhibitors. J Infect 42:251–256
Marks KM, Clarke RM, Bussel JB, Talal AH, Glesby MJ (2009) Risk factors for thrombocytopenia in HIV-infected persons in the era of potent antiretroviral therapy. J Acquir Immune Defic Syndr 52(5):595–599
Sloand EM, Klein HG, Banks SM et al (1992) Epidemiology of thrombocytopenia in HIV infection. Eur J Haematol 48:168–172
Ananworanich J, Phanuphak N, Nuesch R et al (2003) Recurring thrombocytopenia associated with structured treatment interruption in patients with human immunodeficiency virus infection. Clin Infect Dis 37(5):723–726
Arranz Caso JA, Sánchez Mingo C, Garcia Tena J (1999) Effect of highly active antiretroviral therapy on thrombocytopenia in patients with HIV infection. N Engl J Med 341:1239
Scaradavou A (2002) HIV-related thrombocytopenia. Blood Rev 16:73–76
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Nascimento, F.G., Tanaka, P.Y. Thrombocytopenia in HIV-Infected Patients. Indian J Hematol Blood Transfus 28, 109–111 (2012). https://doi.org/10.1007/s12288-011-0124-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12288-011-0124-9