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Collision-induced dissociation pathways of H1-antihistamines by electrospray ionization quadrupole time-of-flight mass spectrometry

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Abstract

Over the past decades, mass spectrometry technologies have been developed to obtain mass accuracies of one ppm or less. Of the newly developed technologies, quadrupole time-of–flight mass spectrometry (Q-TOF–MS) has emerged as being well suited to routine and high-throughput analyses of pharmaceuticals. Dietary supplements and functional foods have frequently been found to be contaminated with pharmaceuticals. In our continuous efforts to develop methodologies to protect public health against adulterated dietary supplements, we have constructed a mass spectral database for 21 H1-antihistamines encountered as adulterants by using liquid chromatography-electrospray ionization (LC-ESI)/Q-TOF–MS, and have proposed their possible collision-induced dissociation pathways. This database will be very useful for the rapid and accurate detection of H1-antihistamines (known) and their analogues (unknown) illegally added to dietary supplements as well as in other sample matrices.

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Acknowledgements

This research was supported by a Grant (13181MFDS724) from the Ministry of Food and Drug Safety in Korea. We thank the Central Laboratory of Kangwon National University for providing us with technical assistance on the spectroscopic experiments.

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    Authors and Affiliations

    1. Advanced Analysis Team, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si, 28159, Republic of Korea

      Jung-Ah Do, Eunyoung Noh, Soon-Byung Yoon, Ji Hyun Lee, Sung-Kwan Park & Sun Young Baek

    2. College of Pharmacy, Kangwon National University, 1 Kangwondaehak-gil, Chuncheon, Gangwon-do, 24341, Republic of Korea

      Suresh Mandava & Jongkook Lee

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    1. Jung-Ah Do
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    Correspondence to Sun Young Baek or Jongkook Lee.

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    Jung-Ah Do and Eunyoung Noh have been contributed equally to this paper.

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    Do, JA., Noh, E., Yoon, SB. et al. Collision-induced dissociation pathways of H1-antihistamines by electrospray ionization quadrupole time-of-flight mass spectrometry. Arch. Pharm. Res. 40, 736–745 (2017). https://doi.org/10.1007/s12272-017-0921-2

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