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A new phenylethanoid glycoside with antioxidant and anti-HBV activity from Tarphochlamys affinis

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Abstract

A new phenylethanoid glycoside, named taraffinisoside A (1), together with five known glycosides were isolated from the stems and leaves of Tarphochlamys affinis. The structure of taraffinisoside A was identified on the basis of detailed spectral analysis. Compounds 1–4 and 6 showed potent antioxidant activities with IC50 values of 10.36, 19.73, 43.95, 15.30 and 46.04 μM by 1,1-diphenyl-2-picryhydrazyl radical-scavenging assay. Compounds 1, 2 and 4 showed anti-HBV activities, with IC50 values of 0.50, 0.72 and 0.26 mM for HBsAg and 0.93, 0.42 and 0.07 mM for HBeAg, respectively.

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Acknowledgments

This work was supported by Guangxi scientific research and technology development research projects (0015048; 10124008-6; 0322024-5E; 0992003A-2), Guangxi Natural Science Foundation (No. 0731066), Guangxi Key Laboratory for Prevention and Treatment of Regional High-Incidence Diseases (KFJJ2010-22); Guangxi science and technology foundation platform construction project (NO. 12-97-20).

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Authors and Affiliations

  1. Pharmaceutical College, Guangxi Medical University, Nanning, Guangxi, 530021, People’s Republic of China

    Xian-Li Zhou, Qing-Wei Wen, Xing Lin, Shi-Jun Zhang, Ying-Xin Li, You-Jia Guo & Ren-Bin Huang

  2. College of Biotechnology, Guilin Medical University, Guilin, Guangxi, 541004, People’s Republic of China

    Xian-Li Zhou

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  1. Xian-Li Zhou
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  2. Qing-Wei Wen
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Correspondence to Ren-Bin Huang.

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Zhou, XL., Wen, QW., Lin, X. et al. A new phenylethanoid glycoside with antioxidant and anti-HBV activity from Tarphochlamys affinis . Arch. Pharm. Res. 37, 600–605 (2014). https://doi.org/10.1007/s12272-013-0219-y

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  • DOI: https://doi.org/10.1007/s12272-013-0219-y

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