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Epigenetic control of stem cell fate to neurons and glia

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Abstract

How a cell fate is determined and how tremendously diverse cells are generated during development are interesting and intriguing questions to be solved before using the stem cells for therapeutic purpose. Recently, it has been suggested that epigenetic control by the histone modifying enzymes and non-coding RNAs play important roles in guiding stem cells to differentiate into neurons or glia. In this review, we discuss the recent outcomes and advances in understanding the histone modifying enzymes and non-coding RNAs during neural cell-type specification of stem cells.

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Authors and Affiliations

  1. Laboratory of Molecular and Stem Cell Pharmacology, College of Pharmacy, Chung-Ang University, Seoul, 156-756, Korea

    Hyun-Jung Kim

  2. Howard Hughes Medical Institute, School of Medicine, California, 92093, Stanford, USA

    Michael G. Rosenfeld

  3. Department of Cellular and Molecular Medicine, University of California, San Diego, School of Medicine, San Diego, California, 92093, USA

    Michael G. Rosenfeld

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  1. Hyun-Jung Kim
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  2. Michael G. Rosenfeld
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Correspondence to Hyun-Jung Kim.

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Kim, HJ., Rosenfeld, M.G. Epigenetic control of stem cell fate to neurons and glia. Arch. Pharm. Res. 33, 1467–1473 (2010). https://doi.org/10.1007/s12272-010-1001-z

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  • DOI: https://doi.org/10.1007/s12272-010-1001-z

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