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Ameliorating effect of capsaicin on alterations in lipid metabolism during mice lung carcinoma

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Abstract

Spices and vegetables possess antioxidant activity that can be applied for preservation of lipids and lower lipid peroxidation in biological systems. In the present study, we have investigated the effect of capsaicin on lipid metabolism during benzo(a)pyrene induced lung cancer in Swiss albino mice. Benzo(a)pyrene (50 mg/kg wt) induced lung cancer animals showed abnormal changes in the tissue and serum lipids, lipoproteins and lipid metabolizing enzymes. Treatment with capsaicin (10 mg/kg body wt) remarkably attenuated all the above alterations and restored normalcy. These findings reveal the chemomodulatory potential of capsaicin in attenuating the alterations in lipid metabolism during experimental lung carcinogenesis.

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Authors and Affiliations

  1. Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India

    P. Anandakumar, S. Jagan, S. Kamaraj, G. Ramakrishnan, J. Binu Clara, D. Pathitha, T. Kavitha & T. Devaki

  2. Department of Biochemistry, University of Madras, Guindy Campus, Chennai, 600 025, Tamil Nadu, India

    T. Devaki

Authors
  1. P. Anandakumar
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  2. S. Jagan
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  3. S. Kamaraj
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  4. G. Ramakrishnan
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  5. J. Binu Clara
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  6. D. Pathitha
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  7. T. Kavitha
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  8. T. Devaki
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Correspondence to T. Devaki.

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Anandakumar, P., Jagan, S., Kamaraj, S. et al. Ameliorating effect of capsaicin on alterations in lipid metabolism during mice lung carcinoma. Arch. Pharm. Res. 32, 229–234 (2009). https://doi.org/10.1007/s12272-009-1140-2

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  • DOI: https://doi.org/10.1007/s12272-009-1140-2

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