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In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E2 biosynthesisb

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Abstract

Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E2 catalysed by COX-2 with an IC50 value of 0.8 μM what is practically the same concentration as the IC50 obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 μM and 0.8 μM, respectively. The COX-1 was inhibited approximately at the same rate (IC50 of 0.7 μM for carvacrol), which suggests non-selective inhibition of both enzyme isoforms. The results of the study demonstrate possible anti-inflammatory potential of this compound due to the inhibition of inducible COX-2 isoform.

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Correspondence to Petr Marsik.

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Landa, P., Kokoska, L., Pribylova, M. et al. In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E2 biosynthesisb. Arch. Pharm. Res. 32, 75–78 (2009). https://doi.org/10.1007/s12272-009-1120-6

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  • DOI: https://doi.org/10.1007/s12272-009-1120-6

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