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Physiologie, Pharmakologie und neue Ansätze für die Therapie der Allergie

Histamin-H4-Rezeptor

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Abstract

Histamine H1-receptor-selective antagonists play an important role in the therapy of allergic rhinitis and conjunctivitis but not in allergic asthma. In asthma, the histamine H4 receptor seems to be a promising therapeutic target. Important experimental tools are H4 receptor knockout mice and H4 receptor antagonists blocking the action of histamine. With H4 receptor knockout mice, the contributions of individual cell types in asthma pathogenesis can be dissected.

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Authors and Affiliations

  1. Institut für Pharmakologie, Medizinische Hochschule Hannover, Jannover, Germany

    Detlef Neumann & Roland Seifert

  2. Institut für Pharmakologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, D-30625, Hannover, Germany

    Detlef Neumann

Authors
  1. Detlef Neumann
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  2. Roland Seifert
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Correspondence to Detlef Neumann.

Additional information

Detlef Neumann Jahrgang 1964. 1985–1991 Biologiestudium an der Universität Hannover. 1995 Promotion zum Dr. rer. nat. 1995–1999 Postdoc bei Dompe SpA, L’Aquila, Italien. Seit 1999 wissenschaftlicher Mitarbeiter (seit 2004 Bereichsleiter Immunpharmakologie) am Institut für Pharmakologie der Medizinischen Hochschule Hannover. 2005 Habilitation im Fach Immunologie. 2009 Habilitation im Fach Molekulare Pharmakologie. 2011 Ernennung zum außerplanmäßigen Professor.

Roland Seifert Jahrgang 1960. 1979–1985 Medizinstudium an der FU Berlin. 1986 Promotion zum Dr. med. 1992 Habilitation für Pharmakologie und Toxikologie. 1995–1998 Postdoc an der Stanford University, CA, USA. 1998–2004 Associate Professor für Pharmakologie an der University of Kansas, Lawrence, USA. 2004–2008 Lehrstuhlinhaber für Pharmakologie und Toxikologie an der Universität Regensburg. Seit 2008 Direktor des Instituts für Pharmakologie der Medizinischen Hochschule Hannover.

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Neumann, D., Seifert, R. Physiologie, Pharmakologie und neue Ansätze für die Therapie der Allergie. Biospektrum 18, 128–132 (2012). https://doi.org/10.1007/s12268-012-0150-7

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  • DOI: https://doi.org/10.1007/s12268-012-0150-7

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