Skip to main content
SpringerLink
Log in

SIRT1 rs3758391 and Major Depressive Disorder: New Data and Meta-Analysis

  • Letter to the Editor
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

T allele versus C allele, square with size by weight and extending line for each study present the OR and 95% CI, respectively. Weight reflects the contribution of each study to the pooled estimate; the latter is shown by a diamond.

References

  1. CONVERGE consortium. Sparse whole-genome sequencing identifies two loci for major depressive disorder. Nature 2015, 523: 588–591.

  2. Luo XJ, Zhang C. Down-regulation of SIRT1 gene expression in major depressive disorder. Am J Psychiatry 2016, 173: 1046.

    Google Scholar 

  3. Hu YY, Wang LY, Chen SF, Liu XH, Li HF, Lu XF, et al. Association between the SIRT1 mRNA expression and acute coronary syndrome. J Atheroscler Thromb 2015, 22: 165–182.

    Article  PubMed  CAS  Google Scholar 

  4. Zhang C, Wu ZG, Zhao GQ, Wang F, Fang YR. Identification of IL6 as a susceptibility gene for major depressive disorder. Sci Rep 2016, 6.

  5. Zhang C, Zhang DF, Wu ZG, Peng DH, Chen J, Ni J, et al. Complement factor H and susceptibility to major depressive disorder in Han Chinese. Br J Psychiatry 2016, 208: 446–452.

    Article  PubMed  Google Scholar 

  6. Zhang C, Wu Z, Hong W, Wang Z, Peng D, Chen J, et al. Influence of BCL2 gene in major depression susceptibility and antidepressant treatment outcome. J Affect Disord 2014, 155: 288–294.

    Article  PubMed  CAS  Google Scholar 

  7. Zhang C, Li ZZ, Wu ZG, Chen J, Wang ZW, Peng DH, et al. A study of N-methyl-D-aspartate receptor gene (GRIN2B) variants as predictors of treatment-resistant major depression. Psychopharmacology 2014, 231: 685–693.

    Article  PubMed  CAS  Google Scholar 

  8. Zhang C, Zhang J, Fan J, Cheng W, Du Y, Yu S, et al. Identification of ANKK1 rs1800497 variant in schizophrenia: new data and meta-analysis. Am J Med Genet B Neuropsychiatr Genet 2014, 165B: 564–571.

    Article  PubMed  CAS  Google Scholar 

  9. Zhang C, Cai J, Zhang J, Li Z, Guo Z, Zhang X, et al. Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2014, 50: 110–115.

    Article  PubMed  CAS  Google Scholar 

  10. Cai J, Zhang W, Yi Z, Lu W, Wu Z, Chen J, et al. Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive-compulsive symptoms. Psychopharmacology (Berl) 2013, 230: 49–55.

    Article  CAS  Google Scholar 

  11. Lu WH, Zhang C, Yi ZH, Li ZZ, Wu ZG, Fang YR. Association between BDNF Val66Met polymorphism and cognitive performance in antipsychotic-naive patients with schizophrenia. J Mol Neurosci 2012, 47: 505–510.

    Article  PubMed  CAS  Google Scholar 

  12. Zhang ZF, Ni JL, Zhang JT, Tang WX, Li X, Wu ZG, et al. A haplotype in the 5’-upstream region of the NDUFV2 gene is associated with major depressive disorder in Han Chinese. J Affect Disord 2016, 190: 329–332.

    Article  PubMed  CAS  Google Scholar 

  13. Ramasamy A, Trabzuni D, Guelfi S, Varghese V, Smith C, Walker R, et al. Genetic variability in the regulation of gene expression in ten regions of the human brain. Nat Neurosci 2014, 17: 1418–1428.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  14. Shi YY, He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 2005, 15: 97–98.

    Article  PubMed  CAS  Google Scholar 

  15. Gu L, Xie J, Long J, Chen Q, Pan R, Yan Y, et al. Epidemiology of major depressive disorder in mainland china: a systematic review. PLoS One 2013, 8: e65356.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  16. Abe-Higuchi N, Uchida S, Yamagata H, Higuchi F, Hobara T, Hara K, et al. Hippocampal Sirtuin 1 signaling mediates depression-like behavior. Biol Psychiatry 2016, 80: 815–826.

    Article  PubMed  CAS  Google Scholar 

  17. Yoshizaki T, Schenk S, Imamura T, Babendure JL, Sonoda N, Bae EJ, et al. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab 2010, 298: E419–428.

    Article  PubMed  CAS  Google Scholar 

  18. Rahman S, Islam R. Mammalian Sirt1: insights on its biological functions. Cell Commun Signal 2011, 9: 11.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Tang L, Chen Q, Meng Z, Sun L, Zhu L, Liu J, et al. Suppression of Sirtuin-1 increases IL-6 expression by activation of the Akt pathway during allergic asthma. Cell Physiol Biochem 2017, 43: 1950–1960.

    Article  PubMed  CAS  Google Scholar 

  20. Volonte D, Zou H, Bartholomew JN, Liu Z, Morel PA, Galbiati F. Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6). J Biol Chem 2015, 290: 4202–4214.

    Article  PubMed  CAS  Google Scholar 

  21. Maciag D, Hughes J, O’Dwyer G, Pride Y, Stockmeier CA, Sanacora G, et al. Reduced density of calbindin immunoreactive GABAergic neurons in the occipital cortex in major depression: relevance to neuroimaging studies. Biol Psychiatry 2010, 67: 465–470.

    Article  PubMed  CAS  Google Scholar 

  22. Hasler G, Northoff G. Discovering imaging endophenotypes for major depression. Mol Psychiatry 2011, 16: 604–619.

    Article  PubMed  CAS  Google Scholar 

  23. Rodriguez de Cordoba S, Esparza-Gordillo J, Goicoechea de Jorge E, Lopez-Trascasa M, Sanchez-Corral P. The human complement factor H: functional roles, genetic variations and disease associations. Mol Immunol 2004, 41: 355–367.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We are deeply grateful to all participants. This work was supported by the National Natural Science Foundation of China (81471358 and 81671326) and the Key Developing Disciplines of Shanghai Municipal Commission of Health and Family Planning, China (2015ZB0405).

Author information

Authors and Affiliations

  1. Department of Psychiatry, Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou, 325000, China

    Wei Tang

  2. Department of Biochemistry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China

    Yan Chen, Xinyu Fang, Yewei Wang & Chen Zhang

  3. Department of Psychiatry, Jinhua Second Hospital, Jinhua, 321016, China

    Weixing Fan

Authors
  1. Wei Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yan Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xinyu Fang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yewei Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Weixing Fan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Chen Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chen Zhang.

Ethics declarations

Conflict of interest

The authors declare that there are no conflicts of interest.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (PDF 242 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tang, W., Chen, Y., Fang, X. et al. SIRT1 rs3758391 and Major Depressive Disorder: New Data and Meta-Analysis. Neurosci. Bull. 34, 863–866 (2018). https://doi.org/10.1007/s12264-018-0235-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-018-0235-5

Search

Navigation