Skip to main content
SpringerLink
Log in

Inhibiting effect of vagal nerve stimulation to seizures in epileptic process of rats

癫痫发作过程中迷走神经刺激对癫痫的抑制作用

  • Article
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

Abstract

Objective

Our previous work suggested that sensitivity of hippocampal neurons is changed in process of epileptic activities, and closely parallel to the dynamic characteristic of epileptic activity of the neurons. This study investigated the sensitivity of epileptic brain to vagal nerve stimulation (VNS) in epileptic process.

Methods

Epileptic model was evoked by penicillin. Left vagal nerves were stimulated to inhibit the seizures induced by penicillin. The electrocorticography (ECoG) and electromyography (EMG) were recorded to analyze inhibiting effect of VNS in epileptic process.

Results

It was found that VNS could inhibit the seizures caused by penicillin, and the inhibiting effect of VNS to seizures increased as the vagal nerve stimulating time prolonged. It was also found that the inhibiting effect of VNS to seizures decreased in epileptic process.

Conclusion

The results suggested that the sensitivity of epileptic brain to VNS was different in epileptic process. The inhibiting effect of VNS to seizure decreased as the development of seizures.

摘要

目的

我们以前的研究发现大鼠海马神经元对刺激的敏感性在癫痫发作过程中是变化的, 并且与神经电活动的非线性动力学特征密切相关。 本研究观察在癫痫发作过程中迷走神经刺激(vagal nerve stimulation, VNS)对癫痫的抑制作用。

方法

在青霉素诱导的大鼠癫痫模型上, 通过记录皮层脑电图和下肢肌电图观察癫痫发作情况, 电刺激左侧颈部迷走神经, 观察 VNS 对癫痫的抑制作用。

结果

VNS 对癫痫活动有明显的抑制作用, 其抑制作用随着刺激时间的延长而增加; 同时发现 VNS 对癫痫的抑制作用在癫痫发作过程是不同的, 癫痫发作开始阶段 VNS 的抑制作用较强, 随着癫痫发作的发展, 其抑制作用逐渐减弱。

结论

大鼠癫痫发作过程中大脑对 VNS 的敏感性是不同的, 随着癫痫的发展, VNS 对癫痫的抑制作用逐渐减弱。

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Casazza M, Avanzini G, Ferroli P, Villani F, Broggi G. Vagal nerve stimulation: relationship between outcome and electroclinical seizure pattern. Seizure 2006, 15: 198–207.

    Article  PubMed  Google Scholar 

  2. Westbrook GL. Seizures and epilepsy. In: Kandel ER, Schwartz JH, Jessell TM, eds. Principles of Neural Science, 4th ed. New York: McGraw-Hill, 2000, 910.

    Google Scholar 

  3. Koch C, Laurent G. Complexity and the nervous system, Science 1999, 284: 96–98.

    Article  PubMed  CAS  Google Scholar 

  4. Rosso OA, Martin MT, Figliola A, Keller K, Plastino A. EEG analysis using wavelet-based information tools. J Neurosci Methods 2006, 153: 163–182.

    Article  PubMed  CAS  Google Scholar 

  5. Andrzejak RG, Widman G, Lehnertz K, Rieke C, David P, Elger CE. The epileptic process as nonlinear deterministic dynamics in a stochastic environment: an evaluation on mesial temporal lobe epilepsy. Epilepsy Res 2001, 44: 129–140.

    Article  PubMed  CAS  Google Scholar 

  6. Yambe T, Asano E, Mauyama S, Shiraishi Y, Shibata M, Sekine K, et al. Chaos analysis of electro encephalography and control of seizure attack of epilepsy patients. Biomed Pharmacother 2005, 59Suppl 1: S236–S238.

    Article  PubMed  Google Scholar 

  7. Iasemidis LD, Shiau DS, Pardalos PM, Chaovalitwongse W, Narayanan K, Prasad A, et al. Long-term prospective on-line real-time seizure prediction. Clin Neurophysiol 2005, 116: 532–544.

    Article  PubMed  CAS  Google Scholar 

  8. Hu SJ, Yang HJ, Jian Z, Long KP, Duan YB, Wan YH, et al. Adrenergic sensitivity of neurons with non-periodic firing activity in rat injured dorsal root ganglion. Neuroscience 2000, 101: 689–698.

    Article  PubMed  CAS  Google Scholar 

  9. Yang HJ, Hu SJ, Han S, Liu GP, Xie Y, Xu JX. Relation between responsiveness to neurotransmitters and complexity of epileptiform activity in rat hippocampal CA1 neurons. Epilepsia 2002, 43: 1330–1336.

    Article  PubMed  CAS  Google Scholar 

  10. Feng Y, Chao DM, Li WM, Cao YX, Wang YQ, Wu GC. Inhibition of nociceptin/orphanin FQ on penicillin-induced seizures in rats. Brain Res 2004, 1020: 214–219.

    Article  PubMed  CAS  Google Scholar 

  11. Groves DA, Bowman EM, Brown VJ. Recordings from the rat locus coeruleus during acute vagal nerve stimulation in the anaesthetised rat. Neurosci Lett 2005, 379: 174–179.

    Article  PubMed  CAS  Google Scholar 

  12. Wheless JW, Baumgartner J. Vagus nerve stimulation therapy. Drugs Today (Barc) 2004, 40: 501–515.

    Article  Google Scholar 

  13. Elger CE, Widman G, Andrzejak R, Arnhold J, David P, Lehnertz K. Nonlinear EEG analysis and its potential role in epileptology. Epilepsia 2000, 41Suppl 3: S34–S38.

    Article  PubMed  Google Scholar 

  14. Yang HJ, Hu SJ, Gong PL, Duan JH. The sensitivity of neurons with non-periodic activity to sympathetic stimulation in rat injured dorsal root ganglion. Neurosci Bull 2006, 22: 14–20.

    PubMed  Google Scholar 

  15. Chaovalitwongse W, Iasemidis LD, Pardalos PM, Carney PR, Shiau DS, Sackellares JC. Performance of a seizure warning algorithm based on the dynamics of intracranial EEG. Epilepsy Res 2005, 64: 93–113.

    Article  PubMed  CAS  Google Scholar 

  16. Adeli H, Ghosh-Dastidar S, Dadmehr N. A wavelet-chaos methodology for analysis of EEGs and EEG subbands to detect seizure and epilepsy. IEEE Trans Biomed Eng 2007, 54: 205–211.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of neurology, Guangzhou military general hospital, Guangzhou, 510010, China

    Hong-Jun Yang  (杨红军), Kai-Run Peng  (彭凯润) & Yan Liu  (刘雁)

  2. Institute of Neuroscience, The Fourth Military Medical University, Xi’an, 710032, China

    San-Jue Hu  (胡三觉)

Authors
  1. Hong-Jun Yang  (杨红军)
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kai-Run Peng  (彭凯润)
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. San-Jue Hu  (胡三觉)
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yan Liu  (刘雁)
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hong-Jun Yang  (杨红军).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yang, HJ., Peng, KR., Hu, SJ. et al. Inhibiting effect of vagal nerve stimulation to seizures in epileptic process of rats. Neurosci. Bull. 23, 336–340 (2007). https://doi.org/10.1007/s12264-007-0050-x

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-007-0050-x

Keywords

关键词

CLC number

Search

Navigation