Abstract
To explore the influence of chemotherapy on prognosis of Head and Neck Squamous Cell Carcinoma (HNSCC) and the relationship between XIAP and CIAP1 co-expression and the prognosis in HNSCC. 129 patients were recruited in our study, they were divided into two groups, neoadjuvant group (n = 60) and non-neoadjuvant group (n = 69). Expression level of XIAP and CIAP1 were examed in neoadjuvant group, and was correlated with clinical outcomes of the patients. The unselected patients were not benefit from neoadjuvant chemotherapy. Moreover, the patients whose tumors co-express high level of XIAP and CIAP1 presented poorer overall and disease-free survival rates than those whose tumors co-express low level of XIAP and CIAP1 (overall survival P < 0.001, disease-free survival P < 0.001). Our results validate that individual chemotherapy is important for HNSCC, and co-expression of XIAP and CIAP1 prompted a worse prognosis.
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We would like to thank professor Jinwei zhang for his help in literature analysis and paper writing.
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Conceived and designed the experiment: XHY LL PZ. Performed the experiments: XHY YJH. Analyzed the data: XHY PZ. Contributed reagents/materials/Analysis tools: PZ QGH. Wrote the paper XHY LL.
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This study was supported by Jiangsu Province’s Key Provincial Youth Talents Program (Grant No.QNRC2016841); Nanjing Municipal Key Medical Laboratory Constructional Project Funding (Since 2012); Center of Nanjing Clinical Medicine Tumor (Since 2014).
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Yang, XH., Liu, L., Hu, YJ. et al. Co-expression of XIAP and CIAP1 Play Synergistic Effect on Patient’s Prognosis in Head and Neck Cancer. Pathol. Oncol. Res. 25, 1111–1116 (2019). https://doi.org/10.1007/s12253-018-0533-2
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DOI: https://doi.org/10.1007/s12253-018-0533-2