References
Vanhaesebroeck B, Stephens L, Hawkins P (2012) PIK3K signaling: the path to discovery and understanding. Nat Rev Mol Cell Biol 13:195–203
Chen M, Nowak DG, Trotman LC (2014) Molecular pathways: PI3K pathway phosphatases as biomarkers for cancer prognosis and therapy. Clin Cancer Res 20:3057–3063
Li Chew C, Lunardi A, Gulluni F, Ruan DT, Chen M, Salmena L, Nishino M, Papa A, Ng C, Fung J, Clohessy JG, Sasaki J, Sasaki T, Bronson RT, Hirsch E, Pandolfi PP (2015) In vivo role of INPP4B in tumor and metastasis suppression through regulation of PI3K–AKT signaling at endosomes. Cancer Discov 5:740–751
Imai K, Yamamoto H (2008) Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics. Carcinogenesis 29:673–680
Je EM, Kim MR, Min KO, Yoo NJ, Lee SH (2012) Mutational analysis of MED12 exon 2 in uterine leiomyoma and other common tumors. Int J Cancer 131:E1044–E1047
Acknowledgments
This work was supported by a grant from National Research Foundation of Korea (2012R1A5A2047939).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Choi, E.J., Kim, M.S., Yoo, N.J. et al. Inactivating Frameshift Mutation of INPP4B Encoding a PI3K Pathway Phosphatase in Gastric and Colorectal Cancers. Pathol. Oncol. Res. 22, 653–654 (2016). https://doi.org/10.1007/s12253-016-0062-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12253-016-0062-9