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Native myocardial T1 mapping using inversion recovery T1-weighted turbo field echo sequence

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Abstract

This study proposes the use of the inversion recovery T1-weighted turbo field echo (IR-T1TFE) sequence for myocardial T1 mapping and compares the results obtained with those of the modified Look-Locker inversion recovery (MOLLI) method for accuracy, precision, and reproducibility. A phantom containing seven vials with different T1 values was imaged, thereby comparing the T1 measurements between the inversion recovery spin-echo (IR-SE) technique, MOLLI, and the IR-T1TFE. The accuracy, precision, and reproducibility of the T1-mapping sequences were analyzed in a phantom study. Fifteen healthy subjects were recruited for the in vivo comparison of native myocardial T1 mapping using MOLLI and IR-T1TFE sequences. After myocardium segmentation, the T1 value of the entire myocardium was calculated. In the phantom study, excellent accuracy was achieved using IR-T1TFE for all T1 ranges. MOLLI displayed lower accuracy than IR-T1TFE (p =0.016), substantially underestimating T1 at large T1 values (> 1000 ms). In the in vivo study, the first mean myocardial T1 values ± SD using MOLLI and IR-T1TFE were 1306 ± 70 ms and 1484 ± 28 ms, respectively, and the second were 1297 ± 68 ms and 1474 ± 43 ms, respectively. The native myocardial T1 obtained with MOLLI was lower than that of IR-T1TFE (p < 0.001). The reproducibility of native myocardial T1 mapping within the same sequence was not statistically significant (p = 0.11). This study demonstrates the utility and validity of myocardial T1 mapping using IR-T1TFE, which is a common sequence. This method was found to have high accuracy and reproducibility.

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All data supporting the findings of this study are available within the paper.

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Funding

No funding was received for conducting this study.

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Authors and Affiliations

  1. Department of Radiological Technology, Faculty of Health Sciences, Okayama University, 2-5-1 Shikata-Cho, Kita-Ku, Okayama-Shi, Okayama, 700-8558, Japan

    Katsuhiro Kida, Ryohei Fukui, Ryutaro Matsuura & Sachiko Goto

  2. Department of Central Radiology, Japanese Red Cross Okayama Hospital, 2-1-1 Aoe, Kita-Ku, Okayama-Shi, Okayama, 700-0941, Japan

    Takamasa Kurosaki

Authors
  1. Katsuhiro Kida
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  2. Takamasa Kurosaki
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  3. Ryohei Fukui
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  4. Ryutaro Matsuura
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  5. Sachiko Goto
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Correspondence to Katsuhiro Kida.

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The authors declare no conflicts of interest.

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This study was approved by the Institutional Review Board of the Japanese Red Cross Okayama Hospital (approval number 2019-66).

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Written informed consent was obtained from all individual participants included in the study.

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Kida, K., Kurosaki, T., Fukui, R. et al. Native myocardial T1 mapping using inversion recovery T1-weighted turbo field echo sequence. Radiol Phys Technol 17, 425–432 (2024). https://doi.org/10.1007/s12194-024-00795-w

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  • DOI: https://doi.org/10.1007/s12194-024-00795-w

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