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Acute myeloid leukaemia with mutated NPM1 presenting with extensive bone marrow necrosis and Charcot–Leyden crystals

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Abstract

Here, we report an unusual case of acute myeloid leukaemia with mutated NPM1 presenting with pancytopenia and leukoerythroblastosis, without circulating blasts and bone marrow necrosis with numerous Charcot–Leyden crystals, but no eosinophilia.

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Acknowledgments

Gordon Taylor, Dominic Culligan and David Grimwade wrote the article. Adam Ivey, David Grimwade and Ben Milner provided the cytogenetic and molecular genetic analysis.

Conflict of interest

The authors state that they have no conflicts of interest relating to this article.

Author information

Authors and Affiliations

  1. Department of Haematology, Aberdeen Royal Infirmary, Aberdeen, UK

    Gordon Taylor & Dominic Culligan

  2. Department of Medical and Molecular Genetics, King’s College London School of Medicine, London, UK

    Adam Ivey & David Grimwade

  3. Department of Medical Genetics, Aberdeen Royal Infirmary, Aberdeen, UK

    Benedict Milner

Authors
  1. Gordon Taylor
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  2. Adam Ivey
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  3. Benedict Milner
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  4. David Grimwade
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  5. Dominic Culligan
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Corresponding author

Correspondence to Gordon Taylor.

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Cite this article

Taylor, G., Ivey, A., Milner, B. et al. Acute myeloid leukaemia with mutated NPM1 presenting with extensive bone marrow necrosis and Charcot–Leyden crystals. Int J Hematol 98, 267–268 (2013). https://doi.org/10.1007/s12185-013-1394-9

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  • DOI: https://doi.org/10.1007/s12185-013-1394-9

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