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Repeated donor lymphocyte infusions overcome a myeloid sarcoma of the stomach resulting from a relapse of acute myeloid leukemia after allogeneic cell transplantation in long-term survival of more than 10 years

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Abstract

A patient with acute myeloid leukemia had a relapse with a myeloid sarcoma of the stomach 32 months after allogeneic bone marrow transplantation. The patient was treated with the first donor lymphocyte infusion (DLI) and one course of induction chemotherapy. Due to severe infectious complication after chemotherapy, the patient could not continue chemotherapy. Subsequently, the patient was treated with a total of 13 cycles of DLI at 1–2 month intervals. Complete remission was achieved and neither relapse nor graft versus host disease has occurred during a follow-up of more than 10 years.

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Acknowledgments

The authors thank all involved clinical staffs. We also thank Reiko Miura and Tsuyoshi Satoh for pathological and technical support, and Midori Ohno for preparing the manuscript. There are no financial conflicts of interest.

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Authors and Affiliations

  1. Department of Hematology, Sapporo Hokuyu Hospital, Hokkaido, Japan

    Akinori Wada, Naoki Kobayashi, Shinsuke Asanuma, Satomi Matsuoka, Mizuha Kosugi, Shiro Fujii, Shinsuke Noguchi, Masanobu Nakata, Shuichi Ota, Kiyotoshi Imai, Teiichi Hirano, Masahiro Ogasawara, Yoshio Kiyama & Masaharu Kasai

  2. Third Department of Internal Medicine, Graduate School of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan

    Akinori Wada & Takayoshi Miyazono

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  1. Akinori Wada
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  2. Naoki Kobayashi
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  3. Shinsuke Asanuma
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  15. Masaharu Kasai
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Correspondence to Akinori Wada.

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Wada, A., Kobayashi, N., Asanuma, S. et al. Repeated donor lymphocyte infusions overcome a myeloid sarcoma of the stomach resulting from a relapse of acute myeloid leukemia after allogeneic cell transplantation in long-term survival of more than 10 years. Int J Hematol 93, 118–122 (2011). https://doi.org/10.1007/s12185-010-0737-z

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  • DOI: https://doi.org/10.1007/s12185-010-0737-z

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