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Use of tranexamic acid for disseminated intravascular coagulation with excessive fibrinolysis associated with aortic dissection in a patient with chronic renal failure

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References

  1. Levi M, Ten Cate H. Disseminated intravascular coagulation. N Engl J Med. 1999;341:586–92. doi:10.1056/NEJM199908193410807.

    Article  CAS  PubMed  Google Scholar 

  2. ten Cate JW, Timmers H, Becker AE. Coagulopathy in ruptured or dissecting aortic aneurysms. Am J Med. 1975;59:171–6. doi:10.1016/0002-9343(75)90351-4.

    Article  CAS  PubMed  Google Scholar 

  3. Micallef-Erynaud PD, Ludlam CA. Aortic aneurysms and consumptive coagulopathy. Blood Coagul Fibrinolysis. 1991;2:477–81. doi:10.1097/00001721-199106000-00012.

    Article  Google Scholar 

  4. Fernandez-Bustamante A, Jimeno A. Disseminated intravascular coagulopathy in aortic aneurysms. Eur J Intern Med. 2005;16:551–60. doi:10.1016/j.ejim.2005.06.015.

    Article  CAS  PubMed  Google Scholar 

  5. Asakura H, Jokaji H, Saito M, Uotani C, Kumabashiri I, Morishita E, et al. Study of the balance between coagulation and fibrinolysis in disseminated intravascular coagulation using molecular markers. Blood Coagul Fibrinolysis. 1994;5:829–32. doi:10.1097/00001721-199410000-00022.

    Article  CAS  PubMed  Google Scholar 

  6. Kario K, Matsuo T, Kodama K, Matsuo M, Yamamoto K, Kobayashi H. Imbalance between thrombin and plasmin activity in disseminated intravascular coagulation. Assessment by the thrombin-antithrombin-III complex/plasmin-alpha-2-antiplasmin complex ratio. Haemostasis. 1992;22:179–86.

    CAS  PubMed  Google Scholar 

  7. Mannucci PM. Hemostatic drugs. N Engl J Med. 1998;23:245–53. doi:10.1056/NEJM199807233390407.

    Article  Google Scholar 

  8. Okajima K, Kohno I, Soe G, Okabe H, Takatsuki K, Binder BR. Direct evidence for systemic fibrinogenolysis in patients with acquired alpha 2-plasmin inhibitor deficiency. Am J Hematol. 1994;45:16–24. doi:10.1002/ajh.2830450104.

    Article  CAS  PubMed  Google Scholar 

  9. Nilsson IM. Clinical pharmacology of aminocaproic and tranexamic acids. J Clin Pathol Suppl (R Coll Pathol). 1980;14:41–7.

    Article  CAS  Google Scholar 

  10. Brandrook ID, Magnani HN, Moelker HC, Morrison PJ, Robinson J, Rogers HJ, et al. ORG 10172: a low molecular weight heparinoid anticoagulant with a long half-life in man. Br J Clin Pharmacol. 1987;23:667–75.

    Article  Google Scholar 

  11. Ontachi Y, Asakura H, Arahata M, Kadohira Y, Maekawa M, Hayashi T, et al. Effect of combined therapy of danaparoid sodium and tranexamic acid on chronic disseminated intravascular coagulation associated with abdominal aortic aneurysm. Circ J. 2005;69:1150–3. doi:10.1253/circj.69.1150.

    Article  PubMed  Google Scholar 

  12. Ontachi Y, Asakura H, Omote M, Yoshida T, Matsui O, Nakao S. Kasabach–Merritt syndrome associated with giant liver hemangioma: the effect of combined therapy with danaparoid sodium and tranexamic acid. Haematologica. 2005;90(Suppl):ECR29.

    PubMed  Google Scholar 

  13. Grand’Maison A, Charest AF, Geerts WH. Anticoagulant use in patients with chronic renal impairment. Am J Cardiovasc Drugs. 2005;5:291–305. doi:10.2165/00129784-200505050-00002.

    Article  PubMed  Google Scholar 

  14. Avvisati G, ten Cate JW, Buller HR, Mandelli F. Tranexamic acid for control of haemorrhage in acute promyelocytic leukaemia. Lancet. 1989;2:122–4. doi:10.1016/S0140-6736(89)90181-5.

    Article  CAS  PubMed  Google Scholar 

  15. Rodeghiero F, Avvisati G, Castaman G, Barbui T, Mandelli F. Early deaths and anti-hemorrhagic treatments in acute promyelocytic leukemia. A GIMEMA retrospective study in 268 consecutive patients. Blood. 1990;75:2112–7.

    CAS  PubMed  Google Scholar 

  16. Sanz MA, Martin G, Gonzalez M, Leon A, Rayon C, Rivas C, et al. Risk-adapted treatment of acute promyelocytic leukemia with all-trans-retinoic acid and anthracycline monotherapy: a multicenter study by the PATHEMA group. Blood. 2004;103:1237–43. doi:10.1182/blood-2003-07-2462.

    Article  CAS  PubMed  Google Scholar 

  17. Hashimoto S, Koike T, Tatewaki W, Seki Y, Sato N, Azegami T, et al. Fatal thromboembolism in acute promyelocytic leukemia during all-trans retinoic acid therapy combined with antifibrinolytic therapy for prophylaxis of hemorrhage. Leukemia. 1994;8:1113–5.

    CAS  PubMed  Google Scholar 

  18. Koseki M, Asada N, Uryu H, Takeuchi M, Asakura H, Matsue K. Successful combined use of tranexamic acid and unfractionated heparin for life-threatening bleeding associated with intravascular coagulation in a patient with chronic myelogenous leukemia in blast crisis. Int J Hematol. 2007;86:403–6. doi:10.1007/BF02983996.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Kosei Matsue.

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Kimura, Si., Odawara, J., Aoki, T. et al. Use of tranexamic acid for disseminated intravascular coagulation with excessive fibrinolysis associated with aortic dissection in a patient with chronic renal failure. Int J Hematol 89, 549–552 (2009). https://doi.org/10.1007/s12185-009-0309-2

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  • DOI: https://doi.org/10.1007/s12185-009-0309-2

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