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The Use of Antibiograms in Orthopedic Surgery

  • Prosthetic Joint Infection (S Nodzo and N Frisch, section editors)
  • Published:
Current Reviews in Musculoskeletal Medicine Aims and scope Submit manuscript

Abstract

Purpose of Review

Organism identification and antibiotic selection remain a critical component of periprosthetic joint infection (PJI) treatment. Prior to organism identification and/or the availability of antibiotic sensitivities, empiric antibiotics are routinely started. A basic understanding of a region or institutions antibiogram is paramount for selection of an empiric treatment regimen. Evolving antibiogram results and regional antibiotic resistance are important to follow as this may change antibiotic selection in some patient populations.

Recent Findings

The Clinical Laboratory and Standards Institute (CLSI) has created guidelines and standards for the creation and maintenance of antibiograms that should be followed by institutions. The infecting organism during PJI may be different in acute vs chronic infections and empiric therapy may change depending on the timing. Antibiotic prophylaxis for major procedures in certain patient populations should be critically evaluated based on regional and national antibiogram results.

Summary

The CLSI guides recommendations and antibiotic resistance testing techniques and should be consulted when creating an antibiogram. The local and regional antibiogram should be consulted prior to administration of empiric and prophylactic antibiotics.

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Author information

Authors and Affiliations

  1. Mike O’Callaghan Medical Center, 4700 N. Las Vegas Blvd, Las Vegas, NV, 89109, USA

    Scott R. Nodzo

  2. Ascension Crittenton Hospital, Rochester, MI, 48304, USA

    Nicholas B. Frisch

Authors
  1. Scott R. Nodzo
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  2. Nicholas B. Frisch
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Correspondence to Scott R. Nodzo.

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Conflict of Interest

Dr. Frisch reports fees from 3M and stock options from PeerWell, outside of the submitted work. Dr. Nodzo declares no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Prosthetic Joint Infection

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Nodzo, S.R., Frisch, N.B. The Use of Antibiograms in Orthopedic Surgery. Curr Rev Musculoskelet Med 11, 341–346 (2018). https://doi.org/10.1007/s12178-018-9496-x

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  • DOI: https://doi.org/10.1007/s12178-018-9496-x

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